New registry tracks Real-World safety of rare disease drug metreleptin

NCT ID NCT02325674

Recruiting now Disease control Sponsor: Chiesi Farmaceutici S.p.A. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 17, 2026 · Updated 3 times

Summary

This registry monitors the safety and effectiveness of metreleptin in up to 100 people with generalized or partial lipodystrophy who are already taking the drug in routine care. Researchers will track serious events like pancreatitis, liver problems, infections, and cancers. The goal is to better understand risks and benefits outside of clinical trials.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: metreleptin
What this could lead to: If successful, this registry will provide real-world safety data on metreleptin, helping doctors better manage lipodystrophy and reduce risks like pancreatitis.
What could go wrong: This is an observational registry, not a controlled trial, so it cannot prove cause and effect. Results depend on voluntary reporting and may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

acquired partial lipodystrophy generalized lipodystrophy lipodystrophy Lipodystrophy, Congenital Generalized partial lipodystrophy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GENERALISED LIPODYSTROPHY PARTIAL LIPODYSTROPHY

Contacts and locations

Show contact details

Study contacts

Contact

Email: •••••@•••••

Locations

Addenbrooke's Hospital
RECRUITING

Cambridge, Cambridge, CB2 0QQ, United Kingdom
Alma Mater Studiorum - Università di Bologna
RECRUITING

Bologna, Bologna, 40126, Italy
Ann & Robert H. Lurie Children's Hospital of Chicago
RECRUITING

Chicago, Illinois, 60611, United States
Atlanta Diabetes Associates
COMPLETED

Atlanta, Georgia, 30318, United States
Azienda Ospedaliera Universitaria Policlinico Tor Vergata
WITHDRAWN

Roma, Roma, 00133, Italy
Azienda Ospedaliero Universitaria Pisana (Presidio di Cisanello)
RECRUITING

Pisa, Pisa, 56124, Italy
CHRU Hôpital Claude Huriez
RECRUITING

Lille, Nord, 59800, France
Children's Hospital of New Orleans/LSU Health Sciences Center
COMPLETED

New Orleans, Louisiana, 70118, United States
Children's Hospital of Philadelphia
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Childrens Hospital of Michigan
RECRUITING

Detroit, Michigan, 48201, United States
City of Hope
TERMINATED

Duarte, California, 91010, United States
Endocrinology Research Associates
RECRUITING

Columbus, Ohio, 43201, United States
Hôpital Robert Debré
RECRUITING

Paris, Paris, France, 75019, France
Hôpital Saint-Antoine
RECRUITING

Paris, Paris, 75012, France
Kinderkrankenhaus Auf der Bult
RECRUITING

Hanover, Lower Saxony, 0000, Germany
Nih/Niddk/Deob
RECRUITING

Bethesda, Maryland, 20892, United States
Ochsner Clinic Foundation
WITHDRAWN

New Orleans, Louisiana, 70121, United States
Richmond University Medical Centre
COMPLETED

Staten Island, New York, 10314, United States
Seattle Children's Hospital
RECRUITING

Seattle, Washington, 98105, United States
UT Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
Universita del Piemonte Orientale "Amedeo Avogadro"
RECRUITING

Novara, Verceilli, 13100, Italy
Universitaetsklinikum Leipzig AoeR
RECRUITING

Leipzig, Saxony, 04103, Germany
Universitaetsklinikum Muenster
RECRUITING

Münster, North Rhine-Westphalia, 48149, Germany
Universitaetsklinikum Ulm
RECRUITING

Ulm, Baden-Wurttemberg, 89075, Germany
University Alabama at Birmingham
TERMINATED

Birmingham, Alabama, 40506, United States
University of Kansas Medical Center Research Institute, Inc.
RECRUITING

Kansas City, Kansas, 66160, United States
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Pennsylvania
WITHDRAWN

Philadelphia, Pennsylvania, 19104, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.