New drug targets cancers missing PTEN gene in early trial

NCT ID NCT04439188

First seen Nov 01, 2025 · Last updated May 12, 2026 · Updated 27 times

Summary

This study tests a drug called GSK2636771 in people whose cancers have lost a gene called PTEN. The drug blocks a protein (PI3K-beta) that helps these cancer cells grow. Researchers want to see if the drug can shrink tumors or stop them from growing. About 35 adults with advanced or hard-to-treat cancers are taking part.

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Contacts and locations

Locations

  • ECOG-ACRIN Cancer Research Group

    Philadelphia, Pennsylvania, 19103, United States

Conditions

Explore the condition pages connected to this study.