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Can bone marrow cells help knee cartilage heal after surgery?

NCT ID NCT05053646

Symptom relief Sponsor: Christian Candrian Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 11, 2026 · Last updated Sep 11, 2026

Summary

Researchers are testing whether adding a marrow venting procedure to standard meniscal repair surgery improves knee function in adults with torn knee cartilage. Participants are 18 to 45 years old with a single suturable meniscal tear. Both groups receive standard arthroscopic repair with sutures, and one group also receives marrow venting, where a surgeon makes small holes in the bone near the knee joint to release marrow cells. The trial measures knee function and symptoms over two years to see if the added step helps recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
marrow venting, a procedure that releases bone marrow cells into the knee during meniscal repair surgery
What this could lead to
If it works, surgeons could add a low-risk step to standard meniscal repair that helps patients recover better knee function and possibly avoid re-tearing.
What could go wrong
Marrow venting may add no benefit over standard repair alone, and any extra surgical step carries small risks such as bleeding, infection, or knee stiffness. The trial is small and results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2021

Expected to finish

Oct 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

16 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Arthroscopic confirmed suturable meniscal tears, * Monolateral meniscal tears, * 18-45 years, * BMI\>18,5 and \<35 kg/m2, * Ability to give informed consent by signature. Exclusion Criteria: * Bilateral meniscal tears requiring treatment, * Associated ligament lesions requiring treatment, * Associated cartilage lesions (Outerbridge \> 2), * Knee axis deformities requiring correction * Generalized ligamentous laxity, * Radiographic knee ostheoarthritis, * Other reasons for knee pain, * Pregnant or lactating women, * Serious systemic diseases such as cardiac, hepatic or renal failure, rheumatic diseases, non-compensated diabetic, psychological illnesses, central or peripheral neurological diseases, and autoimmune diseases, * Enrolled in another ongoing clinical trial.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Meniscal tear

How to take part

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  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Clinica Ars Medica

    RECRUITING

    Lugano, Switzerland

  • Ente Ospedaliero Cantonale

    RECRUITING

    Lugano, 6900, Switzerland

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