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Could a simple mineral cut opioid use in Kids' surgery?

NCT ID NCT06563349

Symptom relief Sponsor: Medical University of Warsaw Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 20, 2026 · Last updated Aug 21, 2026 · Updated 1 time

Summary

This trial investigates whether giving magnesium sulfate through an IV during anesthesia can reduce the need for opioid painkillers in children undergoing laparoscopic appendectomy. It also looks at how magnesium affects heart rate, blood pressure, and stress hormone responses to surgery. Half of the 188 children will receive magnesium, while the other half gets a placebo (saline). The goal is to see if magnesium provides better pain control with fewer opioids.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Intravenous magnesium sulfate infusion
What this could lead to
If effective, this could offer a safer way to manage pain in children after surgery, potentially reducing opioid use and related side effects.
What could go wrong
This is a single-center trial, and results may not apply broadly. Magnesium can affect heart rhythm and blood pressure, so safety monitoring is critical.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 188 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2024

Expected to finish

Nov 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 months to 18 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ASA (American Society of Anesthesiologists) physical status class 1E, 2E, 3E (E - emergency) * Patients undergoing laparoscopic appendectomy Exclusion Criteria: * Allergy to the magnesium sulfate or the excipient * Hypermagnesemia * Renal failure (GFR \<30 ml/min) * Myasthenia gravis * Preoperative atrioventricular block * Hypotension * The use of digitalis glycosides * The use of oral anticoagulants * ASA physical status class 4E or higher * Chronic treatment with analgesics * Legal guardians or patient refusal

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Conditions

The condition(s) this trial relates to.

appendicitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute appendicitis Complication of treatment Multimodal analgesia Opioid consumption

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Uniwersity Clinic Centre of Medical Uniwersity of Warsaw

    RECRUITING

    Warsaw, 02-091, Poland

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