Lung transplant rejection diagnosis gets a molecular makeover

NCT ID NCT02812290

Recruiting now Knowledge-focused Sponsor: University of Alberta Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at lung transplant biopsies to see if molecular testing can better diagnose rejection. Researchers will collect biopsy samples from 700 lung transplant recipients and analyze them using a molecular classifier. The goal is to improve accuracy and potentially develop a safer biopsy method.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could lead to more accurate and safer ways to diagnose lung transplant rejection, potentially reducing the need for invasive biopsies.
What could go wrong: This is an observational study, not a treatment trial. It may not directly improve patient outcomes, and the molecular tests might not prove better than current methods.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

transplant rejection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LUNG TRANSPLANT REJECTION

Contacts and locations

Locations

Alberta Transplant Applied Genomics Centre, University of Alberta
RECRUITING

Edmonton, Alberta, T6G 2E1, Canada
Charles University/Hospital Motol
RECRUITING

Prague, Czechia
Department of Medicine, University of Alberta
RECRUITING

Edmonton, Alberta, T6G 2G3, Canada
Department of Thoracic Surgery, Medical University of Vienna
COMPLETED

Vienna, Austria
Division of Pulmonary and Critical Care, Washington University School of Medicine
COMPLETED

St Louis, Missouri, 63110, United States
St. Joseph's Hospital and Medical Center 350 West Thomas Road, Floor 8HLT
RECRUITING

Phoenix, Arizona, 85013, United States
The Alfred Hospital, Monash University
COMPLETED

Melbourne, Australia
Thoracic Surgery Transplant Clinic
COMPLETED

Szczecin, 70891, Poland
University Health Network, Toronto General Hospital
COMPLETED

Toronto, Ontario, M5G 2C4, Canada
University of Maryland School of Medicine
COMPLETED

Baltimore, Maryland, 21201, United States
University of Texas at San Antonio
COMPLETED

San Antonio, Texas, 21201, United States

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