New drug cocktail aims to outsmart resistant lung cancer

NCT ID NCT06745908

Recruiting now Disease control Sponsor: ImmunityBio, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 28, 2026 · Updated 2 times

Summary

This phase 3 trial tests whether adding an experimental drug (N-803) to standard chemotherapy (docetaxel) can help people with advanced non-small cell lung cancer whose disease has stopped responding to immunotherapy. About 507 participants will be randomly assigned to receive either the combination or chemotherapy alone. The main goal is to see if the combination helps people live longer.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NSCLC STAGE IV

Contacts and locations

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Locations

Barnes-Jewish Hospital - Siteman Cancer Center (Washington University - St. Louis)
RECRUITING

St Louis, Missouri, 63110, United States
Belfast Health and Social Care Trust - Belfast City Hospital
RECRUITING

Belfast, Antrim, BT9 7AB, United Kingdom
Betsi Cadwaladr University Health Board - Glan Clwyd Hospital
RECRUITING

Bodelwyddan, Denbighshire, LL18 5UJ, United Kingdom
Betsi Cadwaladr University Health Board Wrexham Maelor Hospital
RECRUITING

Wrexham, Wrexham, LL13 7TD, United Kingdom
Carolina Oncology Specialists
RECRUITING

Hickory, North Carolina, 28602, United States
Chan Soon-Shiong Institute for Medicine
RECRUITING

El Segundo, California, 90245, United States
Emory University - Winship Cancer Institute
RECRUITING

Atlanta, Georgia, 30322, United States
Highlands Oncology Group
RECRUITING

Springdale, Arkansas, 72762, United States
Holy Cross Hospital
RECRUITING

Fort Lauderdale, Florida, 33308, United States
Horizon Health Network - Saint John Regional Hospital (SJRH)
RECRUITING

Saint John, New Brunswick, E2L 4L2, Canada
London Health Sciences Centre - Verspeeten Family Cancer Centre
RECRUITING

London, Ontario, N6A 5W9, Canada
Medical Oncology Associates - Summit Cancer Centers
RECRUITING

Spokane, Washington, 99208, United States
Medical University of South Carolina
RECRUITING

Charleston, South Carolina, 29425, United States
MemorialCare - Orange Coast Medical Center
RECRUITING

Fountain Valley, California, 92708, United States
Moffit Cancer Center
RECRUITING

Tampa, Florida, 33612-9497, United States
NRS South-East Cancer Research Network
RECRUITING

Edinburgh, Midlothian, EH4 2XR, United Kingdom
OPN Healthcare INC
COMPLETED

Glendale, California, 91203, United States
OPN Healthcare INC/ Cancer and Blood Specialty Clinic
COMPLETED

Los Alamitos, California, 90720, United States
Royal Cornwall Hospitals NHS Trust - Royal Cornwall Hospital
RECRUITING

Truro, Cornwall, TR1 3LJ, United Kingdom
Royal London Hospital
RECRUITING

London, Greater London, NW3 2QG, United Kingdom
Royal Surrey County Hospital NHS Foundation Trust - St Lukes Cancer Centre
RECRUITING

Guildford, Surrey, GU2 7XX, United Kingdom
Southampton General Hospital, Southampton University Hospital National Health Service Trust
RECRUITING

Southampton, Hampshire, SO16 6YD, United Kingdom
Southlake Regional Health Centre
RECRUITING

Newmarket, Ontario, L3Y 2P9, Canada
Tennessee Oncology
RECRUITING

Nashville, Tennessee, 37203, United States
The Oncology Institute of Hope and Innovation
RECRUITING

Fort Lauderdale, Florida, 33316, United States
University Hospital Birmingham NHS Trust
RECRUITING

Birmingham, West Midlands, B9 5SS, United Kingdom
University Hospitals Cleveland Medical Center
RECRUITING

Cleveland, Ohio, 44106, United States

Contact Email: •••••@•••••
University of Cincinnati Medical Center
RECRUITING

Cincinnati, Ohio, 45267, United States
University of Windsor
RECRUITING

Windsor, Ontario, N8W 1L9, Canada
Vancouver Coastal Health
RECRUITING

North Vancouver, British Columbia, V7L 2L7, Canada
Vanderbilt - Ingram Cancer Center
RECRUITING

Nashville, Tennessee, 37232, United States
Velindre NHS Trust - Velindre Cancer Centre VCC
RECRUITING

Cardiff, Glamorgan, CF14 2TL, United Kingdom
Virginia Cancer Specialists
RECRUITING

Fairfax, Virginia, 22031, United States
Virginia Commonwealth University
RECRUITING

Richmond, Virginia, 23219, United States
Waterloo Regional Health Network - Midtown
RECRUITING

Kitchener, Ontario, N2G 1G3, Canada
William Osler Health System - Brampton Civic Hospital
RECRUITING

Brampton, Ontario, L6R 3J7, Canada

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