Blood test could spot lung cancer return risk after surgery

NCT ID NCT04966663

Recruiting now Disease control Sponsor: University Health Network, Toronto Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether a simple blood test that finds cancer DNA can help doctors decide who needs extra treatment after lung cancer surgery. About 66 people who had their lung cancer removed will either get chemo-immunotherapy or just be watched. The goal is to see if the blood test can identify those at high risk of cancer coming back and if the extra treatment helps prevent that.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Nivolumab, Pemetrexed, Gemcitabine, Cisplatin, Carboplatin
What this could lead to: If successful, this could show that using a blood test to detect leftover cancer DNA helps doctors decide who needs extra treatment after surgery, potentially lowering the chance of cancer returning.
What could go wrong: This is a small Phase 2 trial, so results are early and may not apply to everyone. The added chemo-immunotherapy can cause significant side effects, and the blood test may not reliably predict recurrence in all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CIRCULATING TUMOR DNA COMPLETE SURGICAL RESECTION NON-SMALL CELL LUNG CANCER

Contacts and locations

Locations

Princess Margaret Cancer Centre
RECRUITING

Toronto, Ontario, M5G 2M9, Canada

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