A gentler anesthesia cocktail may protect blood pressure during emergency intubation

NCT ID NCT07730918

Completed Disease control Sponsor: Aoyang Hospital Affiliated to Jiangsu University Source: ClinicalTrials.gov ↗

First seen Jul 28, 2026 · Last updated Jul 29, 2026 · Updated 1 time

Summary

This trial tests whether a lower dose of the sedative propofol combined with a higher dose of the fast-acting opioid alfentanil can keep blood pressure and heart rate more stable during rapid-sequence intubation. About 172 adults having planned surgery will receive one of four drug combinations. The main goal is to see if this approach reduces dangerous drops in blood pressure while still allowing the breathing tube to be placed quickly and safely.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: a combination of propofol and alfentanil
What this could lead to: If this approach works, it could point toward a safer way to put people under anesthesia quickly without dangerous drops in blood pressure.
What could go wrong: This is a small, non-randomized study, so results may not apply to all patients. The higher opioid dose could also cause breathing problems or other side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEMODYNAMIC INSTABILITY DURING ANESTHESIA INDUCTION ANESTHESIA INTUBATION

Contacts and locations

Locations

Aoyang Hospital Affiliated to Jiangsu University

Zhangjiagang, Jiangsu, 215600, China

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