New hope for recurrent brain cancer: drug combo targets immune suppressors

NCT ID NCT02669173

First seen Feb 25, 2026 · Last updated May 16, 2026 · Updated 11 times

Summary

This early-phase study tested a combination of two drugs (low-dose capecitabine and bevacizumab) in 12 people whose glioblastoma brain tumors had returned or worsened despite prior treatment. The goal was to see if the treatment could reduce certain immune cells (MDSCs) that help tumors hide from the body's defenses. The study focused on safety and on measuring changes in those immune cells, not on curing the disease.

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Contacts and locations

Locations

  • Cleveland Clinic Taussig Cancer institute, Case Comprehensive Cancer Center

    Cleveland, Ohio, 44195, United States

Conditions

Explore the condition pages connected to this study.