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Hidden flow drop: heart pump output may fall after anesthesia despite normal blood pressure

NCT ID NCT07810621

Knowledge-focused Sponsor: Ataturk University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
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Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 09, 2026 · Last updated Sep 15, 2026 · Updated 3 times

Summary

Researchers are observing adults undergoing coronary artery bypass grafting to see how often cardiac output falls below a set threshold in the 30 minutes after general anesthesia begins. The study uses continuous arterial waveform monitoring to record cardiac index, blood pressure, and related measures every 30 seconds. No treatments or anesthesia routines are changed for the study. The goal is to define and measure this low-flow period, which current blood pressure readings may miss.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If the study identifies a pattern of low cardiac output after anesthesia induction, it could help doctors recognize and respond to reduced blood flow earlier during heart bypass surgery.
What could go wrong
This is an observational study, so it cannot prove that monitoring flow changes outcomes. The findings may not apply to other hospitals, and the small size limits how precisely the results can be estimated.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 103 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2026

Expected to finish

Nov 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adults scheduled for isolated coronary artery bypass grafting with cardiopulmonary bypass at two tertiary cardiovascular surgery centre. Patients are approached before induction of anesthesia and enrolled consecutively. Every eligible patient during the enrollment period enters the cohort and no selection is applied.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 years or older. * Scheduled for elective or emergency cardiac or non-cardiac surgery under general anesthesia. * Availability of peri-operative cardiac output monitoring using the MostCare hemodynamic monitoring system, starting before induction of anesthesia and continuing during surgery. * Availability of required baseline preoperative clinical and laboratory data. * Written informed consent obtained from the participant or legally authorized representative. Exclusion Criteria: * Age under 18 years * Coronary artery bypass grafting combined with valve or aortic surgery * Preoperative mechanical circulatory support * Preoperative infusion of an inotrope or a vasopressor * Technical failure to establish arterial waveform monitoring before induction of anesthesia

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Conditions

The condition(s) this trial relates to.

Cardiac Output, Low coronary artery disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anesthesia, general Cardiac output, low Coronary arterial disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Ankara Bilkent City Hospital

    RECRUITING

    Ankara, Ankara, 06000, Turkey (Türkiye)

  • Ataturk University

    RECRUITING

    Erzurum, Erzurum, 25240, Turkey (Türkiye)

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