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The longevity gene hunt: can families reveal the secret to a long, healthy life?

NCT ID NCT06374069

Knowledge-focused Sponsor: Leiden University Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 26, 2026 · Last updated Aug 27, 2026 · Updated 1 time

Summary

This study looks at Dutch families where members live to very old ages in good health, comparing them with others who do not. The goal is to identify gene variants and lifestyle factors that protect against age-related diseases. By understanding these protective mechanisms, researchers hope to uncover ways to promote healthy aging for everyone.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If this works, it could point toward the genetic and lifestyle factors that protect people from age-related diseases, potentially informing future therapies for healthy aging.
What could go wrong
This is an observational study, so it cannot prove cause and effect. The findings may not apply beyond the Dutch Caucasian population studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 600 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2023

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Dutch Caucasian descent: Ages 75 and older, with siblings enriched for familial longevity, and individuals without a history of familial longevity

Ages

75 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Siblings of Dutch Caucasian descent age 75+ enriched for familial longevity * Individuals of Dutch Caucasian descent age 75+ who are not enriched for familial longevity Exclusion Criteria: \-

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aging Extreme longevity Familial longevity Longevity

Contacts and locations

Locations

  • Leiden University Medical Center

    Leiden, South Holland, 2333ZA, Netherlands

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