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Huntington's drug safety trial ends early: what we know

NCT ID NCT05655520

Terminated Disease control Sponsor: Supernus Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jan 05, 2026 · Last updated May 13, 2026 · Updated 15 times

Summary

This study looked at the long-term safety of an experimental drug called SAGE-718 for people with Huntington's disease. It was a phase 3 trial that planned to enroll 153 participants but was terminated early. The main goal was to track side effects and changes in vital signs, lab results, and heart activity. Because the study was stopped, no conclusions about effectiveness were drawn.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Sage Investigational Site

    Birmingham, Alabama, 35233, United States

  • Sage Investigational Site

    Little Rock, Arkansas, 72205, United States

  • Sage Investigational Site

    La Jolla, California, 92037, United States

  • Sage Investigational Site

    Los Alamitos, California, 90720, United States

  • Sage Investigational Site

    Los Angeles, California, 90095, United States

  • Sage Investigational Site

    Sacramento, California, 95817, United States

  • Sage Investigational Site

    Englewood, Colorado, 80113, United States

  • Sage Investigational Site

    Washington D.C., District of Columbia, 20007, United States

  • Sage Investigational Site

    Boca Raton, Florida, 33431, United States

  • Sage Investigational Site

    Tampa, Florida, 33612, United States

  • Sage Investigational Site

    Chicago, Illinois, 60611, United States

  • Sage Investigational Site

    Chicago, Illinois, 60612, United States

  • Sage Investigational Site

    Indianapolis, Indiana, 46202, United States

  • Sage Investigational Site

    Iowa City, Iowa, 52242, United States

  • Sage Investigational Site

    Kansas City, Kansas, 66103, United States

  • Sage Investigational Site

    Baltimore, Maryland, 21287, United States

  • Sage Investigational Site

    Boston, Massachusetts, 02215, United States

  • Sage Investigational Site

    New York, New York, 10032, United States

  • Sage Investigational Site

    Williamsville, New York, 14221, United States

  • Sage Investigational Site

    Chapel Hill, North Carolina, 27599, United States

  • Sage Investigational Site

    Durham, North Carolina, 27705, United States

  • Sage Investigational Site

    Cincinnati, Ohio, 45219, United States

  • Sage Investigational Site

    Toledo, Ohio, 43614, United States

  • Sage Investigational Site

    Philadelphia, Pennsylvania, 19107, United States

  • Sage Investigational Site

    Charleston, South Carolina, 29425, United States

  • Sage Investigational Site

    Memphis, Tennessee, 38157, United States

  • Sage Investigational Site

    Houston, Texas, 77030, United States

  • Sage Investigational Site

    Richmond, Virginia, 23298, United States

  • Sage Investigational Site

    Spokane, Washington, 99202, United States

  • Sage Investigational Site

    Westmead, New South Wales, 2145, Australia

  • Sage Investigational Site

    Caulfield South, Victoria, 3162, Australia

  • Sage Investigational Site

    Nedlands, Western Australia, 6009, Australia

  • Sage Investigational Site

    Halifax, Nova Scotia, B3S1N2, Canada

  • Sage Investigational Site

    Toronto, Ontario, M2K 1E1, Canada

  • Sage Investigational Site

    Montreal, Quebec, H2X1R9, Canada

  • Sage Investigational Site

    Plymouth, Derriford, PL6 8BT, United Kingdom

  • Sage Investigational Site

    Southampton, England, SO16 6YD, United Kingdom

  • Sage Investigational Site

    Tooting, London, SW17 0QT, United Kingdom

  • Sage Investigational Site

    Aberdeen, Scotland, AB25 2ZA, United Kingdom

  • Sage Investigational Site

    Newcastle, Upon Tyne, NE6 4QD, United Kingdom

  • Sage Investigational Site

    Cardiff, Wales, CF144XW, United Kingdom

  • Sage Investigational Site

    Birmingham, West Midlands, B15 2FG, United Kingdom

  • Sage Investigational Site

    Leeds, West Yorkshire, LS7 4SA, United Kingdom

Conditions

Explore the condition pages connected to this study.

HUNTINGTON'S DISEASE