New drug Mim8 shows promise for Long-Term bleeding prevention in hemophilia a

NCT ID NCT05685238

Recruiting now Disease control Sponsor: Novo Nordisk A/S Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 01, 2026 · Updated 3 times

Summary

This study tests Mim8, a drug that helps blood clot by mimicking a missing protein, in people with hemophilia A (with or without inhibitors). Over 450 participants will receive injections for up to 5.5 years to see if it safely prevents bleeding episodes. The goal is to provide a long-term treatment option that reduces the need for other medications.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Mim8

What this could lead to

If successful, Mim8 could offer a long-term, convenient option to prevent bleeding episodes in people with hemophilia A, reducing the need for frequent infusions.

What could go wrong

This is an extension study, so early results are already promising, but long-term safety and effectiveness are still being confirmed. Some participants may experience side effects or develop antibodies against the drug.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

hemophilia A

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HAEMOPHILIA A HAEMOPHILIA A WITH INHIBITORS

Contacts and locations

Show contact details

Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

A.O.U. Policlinico Umberto I
ACTIVE_NOT_RECRUITING

Rome, Lazio, 00161, Italy
A.O.U. Policlinico Umberto I
ACTIVE_NOT_RECRUITING

Rome, 00161, Italy
AKH - Klin. Abt. f. Haematologie u. Haemostaseologie
ACTIVE_NOT_RECRUITING

Vienna, 1090, Austria
AKH - Klin. Abt. f. Haematologie u. Haemostaseologie
NOT_YET_RECRUITING

Vienna, 1090, Austria
AOU Careggi Firenze
ACTIVE_NOT_RECRUITING

Florence, 50134, Italy
AOU Città della Salute e della Scienza di Torino - Ospedale Regina Margherita
COMPLETED

Torino, 10126, Italy
Acıbadem Adana Hastanesi-Hematoloji
ACTIVE_NOT_RECRUITING

Adana, 01130, Turkey (Türkiye)
Akdeniz Universitesi
RECRUITING

Antalya, 01010, Turkey (Türkiye)
Akdeniz Üniversitesi Hastanesi- Hematoloji
ACTIVE_NOT_RECRUITING

Antalya, Konyaaltı/ Antalya, 01010, Turkey (Türkiye)
AmsterdamUMC AMC
ACTIVE_NOT_RECRUITING

Amsterdam, 1105 AZ, Netherlands
Ap-Hp-Hopital de Bicetre
ACTIVE_NOT_RECRUITING

Le Kremlin-Bicêtre, 94275, France
Ap-Hp-Hopital de Bicetre-1
NOT_YET_RECRUITING

Le Kremlin-Bicêtre, 94275, France
Azienda Ospedaliera Santobono Pausilipon - U.S.D. Centro Regionale Pediatrico Malattie della Coagulazione
ACTIVE_NOT_RECRUITING

Naples, 80122, Italy
Azienda Ospedaliera di Rilievo Nazionale Santobono Pausilipon
RECRUITING

Naples, 80122, Italy
Beijing Children's Hospital, Capital Medical University
ACTIVE_NOT_RECRUITING

Beijing, Beijing Municipality, 100045, China
Beijing Children's Hospital，Capital Medical University
RECRUITING

Beijing, Beijing Municipality, 100045, China
Belfast City Hospital
ACTIVE_NOT_RECRUITING

Belfast, BT9 78B, United Kingdom
CMCV
ACTIVE_NOT_RECRUITING

Ranipet, Tamil Nadu, 632517, India
Central Michigan University
RECRUITING

Detroit, Michigan, 48201, United States
Centre Hospitalier Universitaire de Lille-Institut Coeur Poumon
NOT_YET_RECRUITING

Lille, 59037, France
Centre Hospitalier Universitaire de Nantes-Hopital Hotel-Dieu
ACTIVE_NOT_RECRUITING

Nantes, 44000, France
Centre Hospitalier Universitaire de Nantes-Hopital Hotel-Dieu
NOT_YET_RECRUITING

Nantes, Nantes, France
Centre of Oncology and Hematology, Vilnius University
ACTIVE_NOT_RECRUITING

Vilnius, LT-08406, Lithuania
Centro Multidisciplinario Para El Desarrollo Especializado De La Investigación Clínica En Yucatán S.C.P. (CEMDEICY S.C.P.)
ACTIVE_NOT_RECRUITING

Mérida, 97130, Mexico
Charlotte Maxeke Johannesburg Academic Hospital
ACTIVE_NOT_RECRUITING

Parktown, Johannesburg, Gauteng, 2193, South Africa
Chengdu Women's and Children's Central Hospital
ACTIVE_NOT_RECRUITING

Chengdu, Sichuan, 610074, China
Children University Clinical Hospital
ACTIVE_NOT_RECRUITING

Riga, 1004, Latvia
Children's Healthcare Atlanta
RECRUITING

Atlanta, Georgia, 30329, United States
Children's Hospital Los Angeles - Endocrinology
RECRUITING

Los Angeles, California, 90027, United States
Children's Hospital, Zhejiang University School of Medicine-Hematology
ACTIVE_NOT_RECRUITING

Huzhou, Zhejiang, 313200, China
Christian Medical College and Hospital
ACTIVE_NOT_RECRUITING

Ludhiana, Punjab, 141008, India
Christian Medical College and Hospital
RECRUITING

Ludhiana, Punjab, 141008, India
Chung Shan Medical University Hospital
ACTIVE_NOT_RECRUITING

Taichung, 402, Taiwan
Clinical Centre of Serbia, Institute for Haematology
ACTIVE_NOT_RECRUITING

Belgrade, 11000, Serbia
Clinical Centre of Vojvodina
COMPLETED

Novi Sad, 21000, Serbia
Cliniques universitaires Saint-Luc - Service Hématologie
ACTIVE_NOT_RECRUITING

Brussels, 1200, Belgium
Daejeon Eulji Medical Center, Eulji University
COMPLETED

Daejeon, 35233, South Korea
Daejeon Eulji Medical Center, Eulji University
RECRUITING

Daejeon, 35233, South Korea
Dayton Children Hemostati Ctr
RECRUITING

Dayton, Ohio, 45404, United States
Ege Universitesi Tip Fakultesi
RECRUITING

Bornova-IZMIR, 35100, Turkey (Türkiye)
Ege Üniversitesi Hastanesi- Hematoloji
ACTIVE_NOT_RECRUITING

Bornova-IZMIR, 35100, Turkey (Türkiye)
Evelina London Children's Hospital - Haemophilia
ACTIVE_NOT_RECRUITING

London, SE1 7EH, United Kingdom
Fondazione IRCSS Ca' Granda Ospedale Maggiore Policlinico
ACTIVE_NOT_RECRUITING

Milan, 20122, Italy
Gangdong Kyung Hee University Hospital
RECRUITING

Seoul, 05278, South Korea
Gazi University
NOT_YET_RECRUITING

Ankara, Beşevler/Ankara, 06500, Turkey (Türkiye)
Gazi Üniversitesi Hastanesi- Hematoloji
ACTIVE_NOT_RECRUITING

Ankara, Beşevler/Ankara, 06500, Turkey (Türkiye)
HZRM Haemophilie-Zentrum Rhein Main GmbH
ACTIVE_NOT_RECRUITING

Frankfurt am Main, 60596, Germany
Hacettepe Universitesi
ACTIVE_NOT_RECRUITING

Ankara, 06100, Turkey (Türkiye)
Hacettepe Üniversitesi Hastanesi- Hematoloji
ACTIVE_NOT_RECRUITING

Ankara, 06100, Turkey (Türkiye)
Haemotology, Nanfang Hospital, Southern Medical University
NOT_YET_RECRUITING

Guangzhou, Guangdong, 510515, China
Hospices Civils de Lyon- Hopital Louis Pradel
ACTIVE_NOT_RECRUITING

Bron, 69500, France
Hospital Ampang
ACTIVE_NOT_RECRUITING

Ampang, Selangor, Selangor, 68000, Malaysia
Hospital Ampang
RECRUITING

Ampang, Selangor, Selangor, 68000, Malaysia
Hospital Carlos Haya
RECRUITING

Málaga, 29010, Spain
Hospital Queen Elizabeth 1
ACTIVE_NOT_RECRUITING

Kota Kinabalu, Sabah, 88586, Malaysia
Hospital Regional Universitario de Málaga
ACTIVE_NOT_RECRUITING

Málaga, 29010, Spain
Hospital Sant Joan de Déu
ACTIVE_NOT_RECRUITING

Esplugues Llobregat, 08950, Spain
Hospital Universitario La Paz
ACTIVE_NOT_RECRUITING

Madrid, 28046, Spain
Hospital Vall d'Hebron
ACTIVE_NOT_RECRUITING

Barcelona, 08035, Spain
INSTITUT COEUR POUMON_Service d'hémostase et transfusion
ACTIVE_NOT_RECRUITING

Lille, 59037, France
IRCCS Humanitas Research Hospital - Centro Trombosi e Malattie Emorragiche
ACTIVE_NOT_RECRUITING

Milan, 20089, Italy
Indiana Hemophilia-Thromb Ctr
COMPLETED

Indianapolis, Indiana, 46260, United States
Institut Oncologic "Prof. Dr. Ion Chiricuta" Cluj Napoca
ACTIVE_NOT_RECRUITING

Cluj-Napoca, 400015, Romania
Institute of Hematology and Blood Diseases Hospital, Tianjin-Hematology
ACTIVE_NOT_RECRUITING

Tianjin, Tianjin Municipality, 300020, China
Institute of hematology and Blood Diseases Hospital, Tianjin-Hematology
RECRUITING

Tianjin, Tianjin Municipality, 300020, China
Instytut Hematologii i Transfuzjologii
ACTIVE_NOT_RECRUITING

Warsaw, Masovian Voivodeship, 02-776, Poland
Intytut Hematologii i Transfuzjologii
RECRUITING

Warsaw, Masovian Voivodeship, 02-776, Poland
Istanbul University Oncology Institute
RECRUITING

Capa-ISTANBUL, Capa-ISTANBUL, 34093, Turkey (Türkiye)
Jichi Medical University Hospital_Hematology
ACTIVE_NOT_RECRUITING

Tochigi, 329-0498, Japan
Jichi Medical University Hospital_Pediatrics
ACTIVE_NOT_RECRUITING

Tochigi, 329-0498, Japan
Jinan Central Hospital
ACTIVE_NOT_RECRUITING

Jinan, Shandong, 250062, China
Jinan Central Hospital
RECRUITING

Jinan, 250062, China
Jinan Central Hospital Affiliated to Shandong University
ACTIVE_NOT_RECRUITING

Jinan, Shandong, 250062, China
King Faisal Specialist Hospital & Research Centre, Riyadh
ACTIVE_NOT_RECRUITING

Riyadh, 12713, Saudi Arabia
Kyung Hee University Hospital at Gangdong
ACTIVE_NOT_RECRUITING

Seoul, 05278, South Korea
McMaster University
ACTIVE_NOT_RECRUITING

Hamilton, Ontario, L8N 3Z5, Canada
Nagoya University Hospital_Blood Transfusion
ACTIVE_NOT_RECRUITING

Aichi, 466-8560, Japan
Nanfang Hospital, Southern Medical University-Haematology
ACTIVE_NOT_RECRUITING

Guangzhou, Guangdong, 510515, China
Nara Medical University Hospital_Pediatrics
RECRUITING

Nara, 634-8522, Japan
National Center for Child Health and Development_Hematology
ACTIVE_NOT_RECRUITING

Tokyo, 157-8535, Japan
National Taiwan University Hospital
NOT_YET_RECRUITING

Taipei, 100, Taiwan
National Taiwan University Hospital_main
ACTIVE_NOT_RECRUITING

Taipei, 100, Taiwan
Nirmal Hospital Pvt. Ltd.
ACTIVE_NOT_RECRUITING

Surat, Gujarat, 395002, India
Nirmal Hospital Pvt. Ltd.
RECRUITING

Surat, Gujarat, 395002, India
Ogikubo Hospital_Pediatries & Blood
ACTIVE_NOT_RECRUITING

Tokyo, 167-0035, Japan
Ospedale Pediatrico Bambino Ges
ACTIVE_NOT_RECRUITING

Roma, 00165, Italy
Ospedale Pediatrico Bambino Ges
RECRUITING

Roma, 00165, Italy
Ota Memorial Hospital_Pediatrics
RECRUITING

Gunma, 373-8585, Japan
Penn State MS Hershey Med Ctr
RECRUITING

Hershey, Pennsylvania, 17033-2360, United States
Post Graduate Institute of Child Health
ACTIVE_NOT_RECRUITING

Noida, Uttar Pradesh, 201303, India
Pädiatrische Onkologie-Hämatologie
ACTIVE_NOT_RECRUITING

Lucerne, 6000, Switzerland
Rigshospitalet - Department of Haematology, 2081
ACTIVE_NOT_RECRUITING

København Ø, 2100, Denmark
Royal Free Haemophilia Comprehensive Care Center
ACTIVE_NOT_RECRUITING

London, NW3 2QG, United Kingdom
Royal Free Hospital - Haemophilia
ACTIVE_NOT_RECRUITING

London, NW3 2QG, United Kingdom
Royal Hallamshire Hospital
ACTIVE_NOT_RECRUITING

Sheffield, S10 2JF, United Kingdom
Rush University Med. Cntr
COMPLETED

Chicago, Illinois, 60612, United States
Rush University Medical Center
NOT_YET_RECRUITING

Chicago, Illinois, 60612, United States
SHAT of Haematological Diseases EAD, Clinic of Paediatric Clinical Haematology
ACTIVE_NOT_RECRUITING

Sofia, 1797, Bulgaria
SMS Medical College & Hospital
ACTIVE_NOT_RECRUITING

Jaipur, Rajasthan, 302004, India
Sahyadri Clinical Research And Development Center
ACTIVE_NOT_RECRUITING

Pune, Maharashtra, 411004, India
Sahyadri Clinical Research And Development Center
RECRUITING

Pune, Maharashtra, 411004, India
Saitama Children's Med Centre_Hematology-Oncology
RECRUITING

Saitama, 330-8777, Japan
Seth GS medical college and KEM Hospital
ACTIVE_NOT_RECRUITING

Mumbai, Maharashtra, 400012, India
Seth GS medical college and KEM Hospital
ACTIVE_NOT_RECRUITING

Mumbai, 400012, India
Severance Hospital, Yonsei University Health System
ACTIVE_NOT_RECRUITING

Seoul, 03722, South Korea
Severance Hospital, Yonsei University Health System
NOT_YET_RECRUITING

Seoul, 03722, South Korea
Sheba MC - The Israeli National Hemophilia Center
RECRUITING

Tel Litwinsky, 52621, Israel
St Christopher Hosp for Child
RECRUITING

Philadelphia, Pennsylvania, 19134, United States
St James's CRF
ACTIVE_NOT_RECRUITING

Dublin, Leinster, D08 A978, Ireland
St James's CRF
NOT_YET_RECRUITING

Dublin, Leinster, D08 A978, Ireland
St Joseph's Hospital Foundation
ACTIVE_NOT_RECRUITING

Tampa, Florida, 33607, United States
St Thomas' Hospital - Haemostasis and Thrombosis Centre
ACTIVE_NOT_RECRUITING

London, SE1 7EH, United Kingdom
Stradini Clinic of Oncology
ACTIVE_NOT_RECRUITING

Riga, 1002, Latvia
Szpital Uniwersytecki, Oddzial Kliniczny Hematologii
ACTIVE_NOT_RECRUITING

Krakow, 30-688, Poland
Taichung Veterans General Hospital
ACTIVE_NOT_RECRUITING

Taichung, 407, Taiwan
The Hospital for Sick Children
ACTIVE_NOT_RECRUITING

Toronto, Ontario, M5G 1X8, Canada
Tokyo Medical Univ. Hospital_Laboratory Medicine
ACTIVE_NOT_RECRUITING

Tokyo, 160-0023, Japan
Tongji Hospital, Tongji Medical College of HUST
RECRUITING

Wuhan, Hubei, 430030, China
Tongji Hospital, Tongji Medical College of HUST-Hematology
ACTIVE_NOT_RECRUITING

Wuhan, Hubei, 430030, China
Trakya University
ACTIVE_NOT_RECRUITING

Edirne, 22030, Turkey (Türkiye)
Trakya Üniversitesi Tıp Fakültesi Hastanesi-Hematoloji
ACTIVE_NOT_RECRUITING

Edirne, 22030, Turkey (Türkiye)
UC Denver Hemoph & Thrombo Ctr
RECRUITING

Aurora, Colorado, 80045, United States
ULS De Santo António, E.P.E. _H.Santo António_ Imunohemoterapia
ACTIVE_NOT_RECRUITING

Porto, 4050-342, Portugal
ULS De São José, E.P.E.- Hospital D. Estefânia
ACTIVE_NOT_RECRUITING

Lisbon, 1169-045, Portugal
ULS São João, E.P.E._H.São João_Imunohemoterapia
ACTIVE_NOT_RECRUITING

Porto, 4200-319, Portugal
UMC Utrecht, Van Creveldkliniek
ACTIVE_NOT_RECRUITING

Utrecht, 3584 CX, Netherlands
UZ Leuven - Kindergeneeskunde
ACTIVE_NOT_RECRUITING

Leuven, 3000, Belgium
Unidade De Coimbra, E.P.E. - Hospital da Universidade de Coimbra
ACTIVE_NOT_RECRUITING

Coimbra, 3000-459, Portugal
Univ Hosp Cleveland Med Ctr
RECRUITING

Cleveland, Ohio, 44106, United States
Univ of Miami/SCCC
RECRUITING

Miami, Florida, 33136, United States
University Hospital of Wales - Haemophilia
ACTIVE_NOT_RECRUITING

Cardiff, CF14 4XW, United Kingdom
University of Iowa_Iowa City
RECRUITING

Iowa City, Iowa, 52242, United States
Universitätsklinik für Hämatologie
ACTIVE_NOT_RECRUITING

Bern, 3010, Switzerland
Universitätsklinik für Innere Medizin V
ACTIVE_NOT_RECRUITING

Innsbruck, 6020, Austria
Universitätsklinik für Innere Medizin V
NOT_YET_RECRUITING

Innsbruck, A 6020, Austria
Universitätsklinikum Bonn - Institut für Experimentelle Hämatologie
RECRUITING

Bonn, 53127, Germany
Universitätsspital Zürich - Klinik für Medizinische Onkologie und Hämatologie
ACTIVE_NOT_RECRUITING

Zurich, 8091, Switzerland
Univerzitna Nemocnica Martin
ACTIVE_NOT_RECRUITING

Martin, 036 59, Slovakia
Uniwersytecki Szpital Dzieciecy, Dzial Krwiolecznictwa
RECRUITING

Lublin, 20-093, Poland
Uniwersytecki Szpital Dzieciecy, Dzial Krwiolecznictwa
ACTIVE_NOT_RECRUITING

Lublin, 20-093, Poland
Uniwersytecki Szpital Kliniczny W Poznaniu
ACTIVE_NOT_RECRUITING

Poznan, Greater Poland Voivodeship, 60-569, Poland
Uniwersytecki Szpital Kliniczny im. J.Mikulicza-Radeckiego
RECRUITING

Wroclaw, Lower Silesian Voivodeship, 50-556, Poland
Uniwersytecki Szpital Kliniczny im. J.Mikulicza-Radeckiego
ACTIVE_NOT_RECRUITING

Wroclaw, 50-556, Poland
Vanderbilt U Med Ctr_Nashville
RECRUITING

Nashville, Tennessee, 37212, United States
Vilnius University hospital Santaros klinikos
ACTIVE_NOT_RECRUITING

Vilnius, 08661, Lithuania
Vivantes Netzwerk für Gesundheit GmbH - Vivantes Klinikum im Friedrichshain
RECRUITING

Berlin, 10249, Germany
Vranovska nemocnica, a.s.
ACTIVE_NOT_RECRUITING

Vranov nad Topľou, 09327, Slovakia
Vseobecna nemocnica Rimavska Sobota
ACTIVE_NOT_RECRUITING

Rimavská Sobota, 979 01, Slovakia
Wits Bara Clinical Trial Site
ACTIVE_NOT_RECRUITING

Johannesburg, Gauteng, 2013, South Africa
Xiangya Hospital Central-South University
ACTIVE_NOT_RECRUITING

Changsha, Hunan, 410008, China
Zentrum für Labormedizin
ACTIVE_NOT_RECRUITING

Sankt Gallen, 9008, Switzerland
İstanbul Üniversitesi İstanbul Tıp Fakültesi Hastanesi- Onkoloji Enstitüsü
ACTIVE_NOT_RECRUITING

Capa-ISTANBUL, Capa-ISTANBUL, 34093, Turkey (Türkiye)