New hope for haemophilia a patients: immune training may restore clotting treatment

NCT ID NCT02207894

First seen Apr 25, 2026 · Last updated Apr 30, 2026 · Updated 1 time

Summary

This study tests a treatment called immune tolerance induction (ITI) in 300 people with haemophilia A who have developed inhibitors—antibodies that block standard clotting factor therapy. The goal is to retrain the immune system to accept the clotting factor again, using high doses of personalized factor products. Success is measured by lowering inhibitor levels and restoring normal factor activity and half-life.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Haemophilia Centre Rhine Main

    RECRUITING

    Frankfurt am Main, Hesse, 60596, Germany

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.