New drug trial aims to halt scarring in advanced fatty liver disease

NCT ID NCT06465186

Ongoing Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

Summary

This study is testing whether an investigational drug called efinopegdutide can help treat a serious form of fatty liver disease called MASH that has progressed to cause permanent scarring (cirrhosis). About 80 adults with this condition will receive either the drug or a placebo for 28 weeks to see if it reduces liver fat, inflammation, and scarring. The main goals are to see if the treatment is effective and safe for people whose livers are already damaged.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Aberdeen Royal Infirmary-Department of Gastroenterology ( Site 1102)

Aberdeen, Scotland, AB25 2ZN, United Kingdom
Acclaim Clinical Research ( Site 0137)

San Diego, California, 92120, United States
American Research Corporation ( Site 0131)

San Antonio, Texas, 78215, United States
Arizona Clinical Trials ( Site 0158)

Flagstaff, Arizona, 86001, United States
Assuta Medical Center ( Site 0806)

Tel Aviv, 6789140, Israel
CHU Bordeaux Haut-Leveque-Service d'Hépato-gastroentérologie ( Site 0701)

Pessac, Aquitaine, 33600, France
CHUAC-Complejo Hospitalario Universitario A Coruña-Endocrinología ( Site 1007)

A Coruña, La Coruna, 15006, Spain
CHUS - Hospital Clinico Universitario ( Site 1011)

Santiago de Compostela, La Coruna, 15706, Spain
California Liver Research Institute ( Site 0113)

Pasadena, California, 91105, United States
Carmel Hospital-Liver Unit ( Site 0802)

Haifa, 3436212, Israel
Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren-Hépato-gastroentérologie ( Site 0702)

Limoges, Limousin, 87042, France
Centre Hospitalier Universitaire de Nice - Hôpital l'Archet-Pôle de Référence Hépato Gastro-entérol ( Site 0704)

Nice, Alpes-Maritimes, 06202, France
Chulalongkorn University ( Site 1301)

Bangkok, Bangkok, 10330, Thailand
Coastal Research Institute - Fayetteville ( Site 0159)

Fayetteville, North Carolina, 28304, United States
Delta Research Partners ( Site 0160)

Bastrop, Louisiana, 71220, United States
Diex Recherche Quebec ( Site 0204)

Québec, Quebec, G1V 4T3, Canada
Excel Clinical Research, LLC ( Site 0101)

Las Vegas, Nevada, 89109, United States
Faculty of Medicine Siriraj Hospital-Department of Medicine ( Site 1302)

Bangkok, Bangkok, 10700, Thailand
Flinders Medical Centre-Hepatology and Liver Transplant Medicine ( Site 1202)

Adelaide, South Australia, 5042, Australia
Florida Research Institute ( Site 0116)

Lakewood Rch, Florida, 34211, United States
Floridian Clinical Research, LLC ( Site 0109)

Miami Lakes, Florida, 33016, United States
Fundacion Santa Fe de Bogota ( Site 0403)

Bogotá, Cundinamarca, 110111, Colombia
Fundación Valle del Lili ( Site 0402)

Cali, Valle del Cauca Department, 760032, Colombia
GI Alliance Department of Research ( Site 0162)

Fort Worth, Texas, 76104, United States
HOSPITAL UNIVERSITARIO VIRGEN DEL ROCIO-Unidad de Ensayos clinicos de Aparato Digestivo ( Site 1001)

Seville, 41013, Spain
Homestead Associates in Research, Inc. ( Site 0139)

Homestead, Florida, 33033, United States
Hospital Clínico Universitario de Valladolid-Servicio de Endocrinologia y Nutricion ( Site 1008)

Valladolid, Castille and León, 47010, Spain
Hospital General de Tomelloso-Aparato Digestivo ( Site 1006)

Tomelloso, Ciudad Real, 13700, Spain
Hospital Universitari Vall d'Hebron-Liver Unit - Department of Internal Medicine ( Site 1002)

Barcelona, 08035, Spain
Hospital Universitario La Paz-HEPATOLOGIA ( Site 1005)

Madrid, 28046, Spain
Hospital Universitario Marqués de Valdecilla-Gastroenterology and Hepatology ( Site 1004)

Santander, Cantabria, 39005, Spain
Houston Research Institute ( Site 0117)

Houston, Texas, 77079, United States
Houston Research Institute ( Site 0172)

Houston, Texas, 77004, United States
Huron Gastroenterology ( Site 0102)

Ypsilanti, Michigan, 48197, United States
Hôpital Beaujon-Hépatologie ( Site 0703)

Clichy, Hauts-de-Seine, 92110, France
Hôpital de la Croix Rousse-Centre de Recherche Clinique ( Site 0705)

Lyon, Auvergne-Rhône-Alpes, 69004, France
ISIS CLINICAL RESEARCH CENTER ( Site 0606)

Guaynabo, 00968, Puerto Rico
King's College Hospital ( Site 1104)

London, London, City of, SE5 9RL, United Kingdom
Klinical Investigations Group-Clinical Research ( Site 0601)

San Juan, 00909, Puerto Rico
Louisiana Research Center ( Site 0161)

Shreveport, Louisiana, 71105, United States
Lucas Research, Inc ( Site 0105)

Morehead City, North Carolina, 28557, United States
Maccabi Health Services - Petah Tikva ( Site 0804)

Petah Tikva, 4925110, Israel
Osaka Metropolitan University Hospital ( Site 1403)

Osaka, 545-8586, Japan
Pinnacle Clinical Research ( Site 0104)

Austin, Texas, 78757, United States
Pinnacle Clinical Research-Clinical Research Coordination ( Site 0125)

San Antonio, Texas, 78229, United States
Pinnacle Clinical Research-Corpus Christi ( Site 0156)

Corpus Christi, Texas, 78404, United States
Rambam Health Care Campus ( Site 0801)

Haifa, 3109601, Israel
Rocky Mountain Gastroenterology ( Site 0127)

Littleton, Colorado, 80120, United States
Saga University Hospital ( Site 1405)

Saga, 849-8501, Japan
Shaare Zedek Medical Center ( Site 0805)

Jerusalem, 9103102, Israel
Shinyurigaoka General Hospital ( Site 1401)

Kawasaki, Kanagawa, 215-0026, Japan
Southeast Clinical Research Center ( Site 0119)

Dalton, Georgia, 30720, United States
Southwest Gastroenterology Associates ( Site 0129)

Albuquerque, New Mexico, 87109, United States
St Vincent's Hospital-Gastroenterology Department ( Site 1205)

Melbourne, Victoria, 3065, Australia
Synergy Healthcare ( Site 0118)

Bradenton, Florida, 34209, United States
Texas Clinical Research Institute ( Site 0126)

Arlington, Texas, 76012, United States
The Institute for Liver Health II dba Arizona Clinical Trial-The Institute for Liver Health ( Site 0149)

Chandler, Arizona, 85224, United States
The Institute for Liver Health II dba Arizona Liver Health - Peoria ( Site 0120)

Peoria, Arizona, 85381, United States
The Institute for Liver Health II dba Arizona Liver Health-Tucson ( Site 0111)

Tucson, Arizona, 85712, United States
The Machuca Foundation ( Site 0115)

Las Vegas, Nevada, 89101, United States
Toronto General Hospital ( Site 0207)

Toronto, Ontario, M5G 2C4, Canada
University Hospital,Kyoto Prefectural University of Medicine ( Site 1404)

Kyoto, 602-8566, Japan
University of Virginia Health System ( Site 0164)

Charlottesville, Virginia, 22908, United States
Velocity Clinical Research Rockville ( Site 0143)

Rockville, Maryland, 20854, United States
Velocity Clinical Research, Panorama City ( Site 0124)

Van Nuys, California, 91405, United States
Woodholme Gastroenterology Associates-Woodholme Gastroenterology Associates ( Site 0130)

Glen Burnie, Maryland, 21061, United States
Yokohama City University Hospital ( Site 1402)

Yokohama, Kanagawa, 236-0004, Japan
Zenos Clinical Research ( Site 0136)

Dallas, Texas, 75230, United States

Conditions

Explore the condition pages connected to this study.

METABOLIC DYSFUNCTION ASSOCIATED STEATOHEPATITIS METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE NAFLD NON-ALCOHOLIC FATTY LIVER DISEASE NONALCOHOLIC STEATOHEPATITIS