Liver cancer hope: Immuno-Chemo combo targets tough tumors

NCT ID NCT06904170

Recruiting now Disease control Sponsor: UNICANCER Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial tests whether adding liver-directed chemotherapy (GEMOX) to a two-drug immunotherapy regimen (durvalumab plus tremelimumab) improves outcomes for people with advanced liver cancer that has a high tumor burden. About 196 participants will be randomly assigned to receive immunotherapy alone or with the chemo infusion. The goal is to see if the combination shrinks tumors and extends survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: durvalumab, tremelimumab, gemcitabine, oxaliplatin
What this could lead to: If successful, this could offer a more effective treatment option for people with advanced liver cancer that has a high tumor burden, potentially improving survival.
What could go wrong: This is an early-to-mid-stage trial with only 196 participants, so results may not apply to everyone. Combining immunotherapy with liver-directed chemo may increase side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hepatocellular carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEPATOCELLULAR CARCINOMA

Contacts and locations

Locations

AP-HP Hôpital Beaujon
RECRUITING

Clichy, 92110, France
AP-HP Hôpital Cochin
RECRUITING

Paris, 75014, France
CHRU de Strasbourg
NOT_YET_RECRUITING

Strasbourg, 67091, France
CHU Hôtel-Dieu
NOT_YET_RECRUITING

Nantes, 44093, France
CHU de Bordeaux
NOT_YET_RECRUITING

Bordeaux, 33604, France
CHU de Montpellier
NOT_YET_RECRUITING

Montpellier, 34295, France
CHU de Poitiers
NOT_YET_RECRUITING

Poitiers, 86000, France
CHU de Rangueil
RECRUITING

Toulouse, 31400, France
Centre Eugene Marquis
RECRUITING

Rennes, 35042, France
Centre Georges Francois Leclerc
NOT_YET_RECRUITING

Dijon, 21079, France
Hôpital Saint Joseph
RECRUITING

Marseille, France

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