Heat and chemo: new hope for recurrent glioblastoma?
NCT ID NCT07145112
First seen Nov 01, 2025 · Last updated Jun 23, 2026 · Updated 30 times
Summary
This early-stage trial tests whether combining a laser heat treatment (LITT) with the chemotherapy drug lomustine is safe and feasible for adults with recurrent glioblastoma, an aggressive brain cancer. About 20 participants will receive the laser procedure followed by lomustine within a week. Researchers will track side effects and how many complete the treatment on schedule, with survival followed for up to 2 years.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for GLIOBLASTOMA are added.
By submitting, you agree to our Terms of use
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
University of California Davis Comprehensive Cancer Center
RECRUITINGSacramento, California, 95827, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Lomustine (chemotherapy drug) and laser interstitial thermal therapy (LITT, a heat-based procedure)
What this could lead to
If it works, this could point toward a safer, more effective way to treat recurrent glioblastoma by combining heat ablation with chemotherapy.
What could go wrong
This is a very early, small Phase 1 trial with only 20 people. The main goal is safety, not effectiveness, and the combination may cause serious side effects or fail to improve survival.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.