Could a common blood pressure pill clear lupus brain fog?

NCT ID NCT04486118

Ongoing Disease control Sponsor: Northwell Health Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether two blood pressure drugs, lisinopril and benazepril, can improve memory and concentration in people with lupus. Lupus is an autoimmune disease that can cause inflammation in the brain, leading to cognitive problems. The trial involves 36 adults with lupus and will measure changes in brain activity and cognitive function over 12 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Lisinopril (a blood pressure drug) and benazepril (another blood pressure drug)
What this could lead to: If it works, this could point toward a treatment for lupus-related memory and concentration problems.
What could go wrong: This is a small, early-phase trial with only 36 people, so results may not apply to everyone. It is also testing two similar drugs, so the difference between them may be small.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

systemic lupus erythematosus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SYSTEMIC LUPUS ERYTHEMATOSUS

Contacts and locations

Locations

Albert Einstein College of Medicine

The Bronx, New York, 10461, United States
Andrew Shaw

Manhasset, New York, 11030, United States
Columbia University Medical Center

New York, New York, 10032, United States
Hospital for Special Surgery

New York, New York, 20021, United States
New York University School of Medicine

New York, New York, 10016, United States
Northwell Rheumatology

Great Neck, New York, 11021, United States
Yale University School of Medicine

New Haven, Connecticut, 06519, United States

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