Could a common blood pressure pill clear lupus brain fog?
NCT ID NCT04486118
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tests whether two blood pressure drugs, lisinopril and benazepril, can improve memory and concentration in people with lupus. Lupus is an autoimmune disease that can cause inflammation in the brain, leading to cognitive problems. The trial involves 36 adults with lupus and will measure changes in brain activity and cognitive function over 12 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Lisinopril (a blood pressure drug) and benazepril (another blood pressure drug)
What this could lead to
If it works, this could point toward a treatment for lupus-related memory and concentration problems.
What could go wrong
This is a small, early-phase trial with only 36 people, so results may not apply to everyone. It is also testing two similar drugs, so the difference between them may be small.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Albert Einstein College of Medicine
The Bronx, New York, 10461, United States
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Andrew Shaw
Manhasset, New York, 11030, United States
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Columbia University Medical Center
New York, New York, 10032, United States
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Hospital for Special Surgery
New York, New York, 20021, United States
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New York University School of Medicine
New York, New York, 10016, United States
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Northwell Rheumatology
Great Neck, New York, 11021, United States
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Yale University School of Medicine
New Haven, Connecticut, 06519, United States