New combo therapy aims to outsmart resistant blood cancer

NCT ID NCT06104566

Recruiting now Disease control Sponsor: Ascentage Pharma Group Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 trial is testing whether adding a new drug called lisaftoclax to a standard BTK inhibitor works better than the BTK inhibitor alone for people with CLL or SLL whose cancer has come back or not responded well to prior BTK inhibitor treatment. About 400 participants will be randomly assigned to one of two groups. The main goal is to see if the combination helps people live longer without their cancer getting worse.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: lisaftoclax (APG-2575) combined with a BTK inhibitor
What this could lead to: If successful, this combination could offer a more effective treatment option for people with CLL/SLL whose disease has progressed on BTK inhibitor therapy alone.
What could go wrong: This is an early-stage Phase 3 trial, so results are not guaranteed. The combination may cause more side effects than the single drug, and it may not improve survival or delay disease progression for all patients.

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Conditions

The condition(s) this trial relates to.

chronic lymphocytic leukemia/small lymphocytic lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CLL/SLL

Contacts and locations

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Study contacts

Contact

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Contact

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Locations

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Tuscon, Arizona, 85742, United States
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Anaheim, California, 92805, United States
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Jacksonville, Florida, 32224, United States
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Miami Beach, Florida, 33140, United States
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Peoria, Illinois, 61615, United States
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Boston, Massachusetts, 02215, United States
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Ann Arbor, Michigan, 48109, United States
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Greenville, North Carolina, 27834, United States
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Houston, Texas, 77030, United States

Contact
Ascentage Investigative Site
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Kingswood, Texas, 77339, United States
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Richmond, Virginia, 23298, United States
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Gosford, 2250, Australia
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Perth, 6000, Australia
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Westmead, 2145, Australia
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Ghent, 9000, Belgium
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La Louvière, 7100, Belgium
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Leuven, 3000, Belgium
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Ottignies, 1349, Belgium
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Roeselare, 8800, Belgium
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Sofia, 1407, Bulgaria
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Sofia, 1431, Bulgaria
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Sofia, 1756, Bulgaria
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Sofia, 1797, Bulgaria
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Halifax, Nova Scotia, B3S 0H6, Canada
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Hefei, Anhui, 230031, China
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Beijing, Beijing Municipality, 100005, China
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Fuzhou, Fujian, 350001, China
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Foshan, Guangdong, 528000, China
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Guangzhou, Guangdong, 510050, China
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Nanning, Guangxie, 530022, China
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Zhengzhou, Henan, 450003, China
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Wuhan, Hubei, 430022, China
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Chenzhou, Hunan, 423000, China
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Nanjing, Jiangsu, 210029, China
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Suzhou, Jiangsu, 215026, China
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Wuxi, Jiangsu, 214023, China
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Nanchang, Jiangxi, 330008, China
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Xi'an, Shaanxi, 710061, China
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Binzhou, Shandong, 256600, China
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Taiyuan, Shanxi, 030013, China
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Luzhou, Sichuan, 646099, China
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Yibin, Sichuan, 644099, China
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Guangzhou, 510090, China
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Hradec Králové, 500 05, Czechia
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Clermont-Ferrand, 63000, France
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Le Mans, 72037, France
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Lyon, 69373, France
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Nantes, 44000, France
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Nantes, 44277, France
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Nîmes, 30029, France
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Orléans, 45100, France
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Poitiers, 86000, France
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Pontoise, 95300, France
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Strasbourg, 67091, France
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Tours, 37000, France
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Dresden, 01307, Germany
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Dresden, 48149, Germany
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München, 81377, Germany
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Gandhinagar, Gujarat, 382428, India
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Gurugramam, Haryana, 122001, India
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Gurugramam, Haryana, 122002, India
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Jhajjar, Haryana, 124105, India
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Bangalore, Karnataka, 560027, India
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Mysuru, Karnataka, 570023, India
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Navi Mumbai, Maharashtra, 400614, India
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Pune, Maharashtra, 411001, India
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Delhi, National Capital Territory of Delhi, 110085, India
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New Delhi, New Delhi, 110017, India
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New Delhi, New Delhi, 110029, India
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New Delhi, New Delhi, 110076, India
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New Delhi, New, 110017, India
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Madurai, Tamil Nadu, 625020, India
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Hyderabad, Telangana, 500033, India
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Kolkata, West Bengal, 700014, India
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Kolkata, West Bengal, 700054, India
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Puducherry, 605006, India
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Haifa, 31048, Israel
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Haifa, 3109601, Israel
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Jerusalem, 91120, Israel
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Kfar Saba, 4428164, Israel
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Tel Aviv, 62431, Israel
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Aviano, 33081, Italy
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Brescia, 25123, Italy
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Cona, 44124, Italy
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Genova, 16132, Italy
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Lecce, 73100, Italy
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Meldola, 47014, Italy
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Milan, 20141, Italy
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Milan, 20132, Italy
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Padova, 35122, Italy
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Piacenza, 29121, Italy
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Ravenna, 48121, Italy
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Reggio Emilia, 42123, Italy
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Rimini, 47923, Italy
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Roma, 00128, Italy
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Roma, 00168, Italy
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Torino, 10126, Italy
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Udine, 33100, Italy
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Bydgoszcz, 85-048, Poland
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Krakow, 30-727, Poland
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Lodz, 93-513, Poland
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Skorzewo, 60-185, Poland
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Bucharest, 022328, Romania
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Cluj-Napoca, 400015, Romania
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Timișoara, 300254, Romania
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Saint Petersburg, Kaluga Oblast, 248008, Russia
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Kirov, Kirov Oblast, 610027, Russia
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Kaluga, 246007, Russia
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Kazan', 420029, Russia
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Moscow, 115522, Russia
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Moscow, 123182, Russia
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Moscow, 125284, Russia
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Petrozavodsk, 185019, Russia
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Saint Petersburg, 197022, Russia
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Saint Petersburg, 197341, Russia
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Sochi, 354057, Russia
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Syktyvkar, 167904, Russia
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Bratislava, 833 10, Slovakia
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Martin, 036 59, Slovakia
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Barcelona, 08003, Spain
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Barcelona, 08035, Spain
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Palma de Mallorca, 07120, Spain
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Santander, 39008, Spain
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Valencia, 46015, Spain
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Kepez, 07025, Turkey (Türkiye)
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Trabzon, 31080, Turkey (Türkiye)
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Birmingham, B15 2GW, United Kingdom
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Bournemouth, BH7 7DW, United Kingdom
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Liverpool, L7 8YA, United Kingdom
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London, SW3 6JJ, United Kingdom
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Manchester, M20 4BX, United Kingdom
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Stoke-on-Trent, ST4 6QG, United Kingdom
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Swansea, SA2 8QA, United Kingdom
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West Bromwich, B71 4HJ, United Kingdom
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Wolverhampton, WV10 0QP, United Kingdom

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