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New anesthesia combo may prevent dangerous blood pressure drops in emergency surgery

NCT ID NCT06772727

Symptom relief Sponsor: Cairo University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

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Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
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Status unknown
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First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether using lidocaine instead of opioids during anesthesia induction can prevent low blood pressure in adults having emergency abdominal surgery. 149 patients were randomly assigned to receive either lidocaine-based or opioid-based anesthesia. The main goal was to see how often low blood pressure occurred right after anesthesia was given.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

149 people

The number who actually took part.

Started

Feb 2025

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Adult patients 2. Both gender 3. American Society of Anesthesiologists (ASA) class I-III undergoing emergency laparotomy. Exclusion Criteria: 1. Patient refusal 2. Severe cardiac morbidities (impaired contractility with ejection fraction \< 45%, heart block, arrhythmias, tight valvular lesions) 3. Baseline mean arterial pressure \<75 mmHg 4. Patients on vasopressor infusion, 5. Patients with high shock index (heart rate / systolic blood pressure \>1) 6. Pregnant or lactating women, 7. Allergy of any of the study drugs 8. Uncontrolled hypertension 9. Opioid drug abusers 10. Patients with increased intracranial tension

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Emergency laparotomy Lidocaine OPIOID Post-induction hypotension

Contacts and locations

Locations

  • Faculty of Medicine, Cairo University

    Cairo, Egypt

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