Designer immune cells take on rare sarcomas

NCT ID NCT05993299

Ongoing Disease control Sponsor: USWM, LLC (dba US WorldMeds) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial tests a personalized cell therapy called Lete-Cel in 7 people with advanced synovial sarcoma or myxoid/round cell liposarcoma that has not been treated before. Participants receive their own immune cells that have been engineered to recognize and attack their cancer, along with chemotherapy to prepare the body. The main goal is to see if the tumors shrink or disappear.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Letetresgene autoleucel (engineered immune cells) given with chemotherapy drugs cyclophosphamide and fludarabine
What this could lead to: If it works, this could offer a new treatment option for people with certain advanced sarcomas that have few other choices.
What could go wrong: This is a very small, early-phase trial with only 7 participants. The therapy may not shrink tumors or could cause serious side effects from the chemotherapy or cell infusion.

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Conditions

The condition(s) this trial relates to.

myxoid/round cell liposarcoma neoplasm synovial sarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NEOPLASMS

Contacts and locations

Locations

CHU de Bordeaux GH Sud Hôpital Haut Lévêque

Pessac, 33604, France
CIUSSS de L'Est-De-Lile-De-Montreal

Montreal, Quebec, H1T 2M4, Canada
Centre Léon Bérard

Lyon, 69373, France
Christie Hospital NHS Foundation Trust

Manchester, M20 4BX, United Kingdom
City of Hope National Medical Center

Duarte, California, 91010, United States
Dana Farber Cancer Institute

Boston, Massachusetts, 02114, United States
Duke University Medical Center

Durham, North Carolina, 27710, United States
Fondazione IRCCS Instituto Nazionale Dei Tumori

Milan, 20133, Italy
Fred Hutchinson Cancer Research Center

Seattle, Washington, 98109-1024, United States
Froedtert Hospital

Milwaukee, Wisconsin, 53226, United States
Hospital Santa Creu Y Sant Pau

Barcelona, 08025, Spain
Hospital Universitario Fundación Jiménez Díaz

Madrid, 28040, Spain
Hospital Virgen Del Rocio

Seville, 41013, Spain
Ico Duran y Reynals l'Hospitalet de Llobrega

Hospitalet de Llobregat, Barcelona, 08907, Spain
Ircss Istituto Clinico Humanitas

Romano di Lombardia, 20089, Italy
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Mayo Clinic Jacksonville

Jacksonville, Florida, 32224, United States
Mayo Clinic Rochester

Rochester, Minnesota, 55905, United States
Memorial Sloan Kettering cancer center

New York, New York, 10065, United States
Minnesota Oncology Hematology

Minneapolis, Minnesota, 55455, United States
Ohio State University-Columbus

Columbus, Ohio, 43210, United States
Oregon Health and Science University

Portland, Oregon, 97239, United States
Princess Margaret Cancer Centre

Toronto, M5G 2M9, Canada
Royal Marsden Hospital

London, SW3 6JJ, United Kingdom
Sarah Cannon Research Institute

Denver, Colorado, 80218, United States
Stanford Hospital and Clinics

Stanford, California, 94305, United States
Tennessee Oncology

Nashville, Tennessee, 37203, United States
The Netherlands Cancer Institute

Amsterdam, 1066 CX, Netherlands
University College Hospital-London

London, WC1E 6AG, United Kingdom
University Of Texas Southwestern Medical Center

Dallas, Texas, 75390-8565, United States
University of Chicago

Chicago, Illinois, 60637, United States
University of Iowa College of Medicine

Iowa City, Iowa, 52242-1009, United States
University of Michigan Medical Center

Ann Arbor, Michigan, 48109, United States
University of Pittsburgh, Hillman Cancer centre

Pittsburgh, Pennsylvania, 15232, United States
University of Texas Southwestern Medical Center

Dallas, Texas, 75390-9063, United States
University of Utah

Salt Lake City, Utah, 84112, United States
Virginia Commonwealth University

Richmond, Virginia, 23298, United States
Washington University

St Louis, Missouri, 63110, United States

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