Could a common supplement ease heart strain in kids with sickle cell?
NCT ID NCT05470998
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether L-Arginine, a natural amino acid, could improve heart function in children with sickle cell disease who have increased blood pressure in their lungs. Fifty children aged 5-18 took L-Arginine capsules for 3 months. Researchers measured changes in heart blood flow and blood markers to see if the supplement helped reduce heart strain.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- L-Arginine
- What this could lead to
- If it works, this could point toward a simple supplement to help manage heart-related complications in children with sickle cell disease.
- What could go wrong
- This is a small, completed Phase 3 trial with only 50 participants. The results may not apply to all children with sickle cell disease, and L-Arginine may not significantly improve heart function.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for SICKLE CELL DISEASE are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Tanta university
Tanta, Other (Non U.s.), Egypt
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can Co-Designed support help parents embrace sickle cell care?
- Can community hospitals in zambia master severe disease care?
- A Pocket-Sized coach for sickle cell: can an app turn Pill-Taking into a habit?
- Can a phone app keep teens on track with sickle cell treatment?
- A common amino acid may calm sickle cell pain crises — a trial puts it to the test
- A drug that protects the liver may make stem cell transplants safer for children with sickle cell disease