Could a common supplement ease heart strain in kids with sickle cell?
NCT ID NCT05470998
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether L-Arginine, a natural amino acid, could improve heart function in children with sickle cell disease who have increased blood pressure in their lungs. Fifty children aged 5-18 took L-Arginine capsules for 3 months. Researchers measured changes in heart blood flow and blood markers to see if the supplement helped reduce heart strain.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
L-Arginine
What this could lead to
If it works, this could point toward a simple supplement to help manage heart-related complications in children with sickle cell disease.
What could go wrong
This is a small, completed Phase 3 trial with only 50 participants. The results may not apply to all children with sickle cell disease, and L-Arginine may not significantly improve heart function.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Tanta university
Tanta, Other (Non U.s.), Egypt