Hunting the genes behind calcium kidney stones
NCT ID NCT05972408
First seen Sep 10, 2026 · Last updated Sep 11, 2026 · Updated 1 time
Summary
Researchers at Mansoura Urology and Nephrology Center in Egypt are studying patients with kidney stones to learn how common calcium-based stones are and whether certain gene variants play a role. The study enrolls about 84 people, including patients who need stone removal and healthy controls without urinary problems. Participants provide stone samples for chemical analysis and blood for genetic testing of the VDR and CASR genes. The team also tracks whether stones come back within two years after treatment.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If researchers link specific gene variants to calcium kidney stones, doctors could one day use a genetic test to spot people at higher risk and tailor prevention.
- What could go wrong
- This is a small observational study at a single center in Egypt, so its findings may not apply to other populations. It looks for associations, not proof that genes cause stones.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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84 people
The number who actually took part.
- Started
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Mar 2021
- Finished
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Jan 2024
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
All patients with unilateral or bilateral renal stones (de novo or recurrent) who were candidates for endoscopic or surgical intervention
- Ages
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Children (under 18), adults (18 to 64) and older adults (65 and over)
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * All patients with unilateral or bilateral renal stones (de novo or recurrent) who were candidates for endoscopic or surgical intervention were included. Metabolic workup was done for selected patients with radio-opaque stones, while genetic testing was done for those with dominant Ca composition proven by postoperative stone analysis. Thirty healthy individuals with no urologic abnormalities were involved as control cases. Patients with renal calculi for whom metabolic and genetic testing were performed are designated "α" cases. Exclusion Criteria: * For metabolic and genetic testing, patients with a well-known lesion precipitating stone disease were excluded e.g. ureteric stricture, ureteropelvic or ureterovesical junction obstruction, urinary diversion, history of ureterovesical re-implantation as well as patients with non-Ca stones by post-operative stone analysis
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Mansoura University
Al Mansurah, Outside U.S./Canada, 35561, Egypt
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