Ketone infusion tested as potential heart helper for diabetics

NCT ID NCT03560323

First seen Nov 01, 2025 · Last updated Apr 09, 2026 · Updated 26 times

Summary

This early-phase study investigated whether raising ketone levels in the blood could improve heart function in people with both type 2 diabetes and heart failure. Researchers gave 41 participants infusions of a ketone substance at different doses and used heart scans (MRI and PET) to measure changes in how well the heart pumped blood and used fuel. The goal was to understand a possible mechanism behind why certain diabetes drugs seem to benefit the heart.

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Contacts and locations

Locations

  • Texas Diabetes Institute - University Health System

    San Antonio, Texas, 78207, United States

  • University of Texas Health Science Center San Antonio

    San Antonio, Texas, 78229, United States

Conditions

Explore the condition pages connected to this study.