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Can a ketogenic diet tame acromegaly hormones?

NCT ID NCT07100587

Disease control Sponsor: University of Palermo Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested whether a three-week ketogenic diet could improve hormone and metabolic measures in 26 adults with active acromegaly, compared to a Mediterranean diet. Participants followed each diet for three weeks, with a two-week break in between. The main goal was to see changes in IGF-1 levels, along with weight, blood sugar, and inflammation markers.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ketogenic diet and Mediterranean diet
What this could lead to
If successful, this could show that a short-term ketogenic diet helps control hormone levels and improve metabolic health in people with acromegaly.
What could go wrong
This is a small, early-stage study with only 26 participants and short diet periods. Results may not apply to all patients, and the ketogenic diet can be hard to follow long-term.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

26 people

The number who actually took part.

Started

Jun 2024

Finished

Jul 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years * Confirmed diagnosis of active acromegaly (elevated IGF-1, GH non-suppressible at OGTT) * Stable medical therapy for ≥ 3 months * BMI 25-40 kg/m² * Informed consent signed Exclusion Criteria: * Type 1 diabetes or insulin-treated type 2 diabetes mellitus * History of ketoacidosis * Active malignancy, decompensated liver/kidney disease * Severe psychiatric disorders or eating disorders * Pregnancy or breastfeeding

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Conditions

The condition(s) this trial relates to.

acromegaly

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acromegaly

Contacts and locations

Locations

  • Policlinico Paolo Giaccone

    Palermo, Italy

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