Keto diet may raise 'Bad' cholesterol differently depending on your weight
NCT ID NCT06515912
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed study from Penn State University looked at how a strict 4-week ketogenic diet (very low carb, high fat) affects blood cholesterol and heart health in 25 healthy adults. Researchers compared people with a healthy BMI to those with obesity to see if the diet raises 'bad' LDL cholesterol more in one group. Participants ate only study-provided meals and had fasting blood tests and vascular function measurements before and after the diet.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Ketogenic diet (5% carbs, 18% protein, 77% fat)
What this could lead to
If successful, this could help clarify how the ketogenic diet affects heart disease risk differently in people with healthy weight versus obesity.
What could go wrong
This is a small, short-term study (25 people, 4 weeks) that only measures changes in blood lipids and vascular function, not actual heart disease outcomes. Results may not apply to the general population.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for CARDIOVASCULAR DISEASES are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Penn State University
University Park, Pennsylvania, 16802, United States