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Can adding ketamine to propofol improve sleep apnea scans?

NCT ID NCT04452383

Diagnosis Sponsor: Zagazig University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 10, 2026 · Last updated Sep 11, 2026 · Updated 1 time

Summary

Researchers test whether adding ketamine to propofol improves sedation for drug-induced sleep endoscopy in adults with obstructive sleep apnea. The procedure lets doctors see where the airway collapses during sleep. Thirty adults receive either propofol alone or propofol plus ketamine. The team measures how often the procedure is completed successfully and how quickly sufficient sedation is reached.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ketamine added to propofol
What this could lead to
If adding ketamine helps, doctors could get clearer pictures of airway blockages during sleep endoscopy, which may guide better treatment choices for sleep apnea.
What could go wrong
This is a small, single-center study of 30 people, so results may not apply broadly. Ketamine can cause hallucinations or blood pressure changes, and the combination might not work better than propofol alone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

30 people

The number who actually took part.

Started

Jul 2024

Finished

Dec 2025

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria * Age \> 18 years old. * American society of anesthesiologists (ASA) physical status I or II. I / II Exclusion Criteria: * patient refusal * American society of anesthesiologists (ASA) physical status \> III * known or suspected allergy to the studied drugs or its components, allergy to eggs or soy beans * morbid obesity * patients with moderate to severe chronic obstructive pulmonary disease or uncontrolled asthma, congestive e heart failure ,seizures ,or cerebrovascular disease * pregnancy

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Conditions

The condition(s) this trial relates to.

obstructive sleep apnea syndrome sleep apnea syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Sleep apnea syndromes

Contacts and locations

Locations

  • zagazig University

    Zagazig, Sarkia, 44519, Egypt

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