New drug JBZ-001 enters first human trial for Hard-to-Treat cancers
NCT ID NCT06801002
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage trial is testing a new oral drug called JBZ-001 in 25 adults with advanced solid tumors or certain blood cancers (like lymphoma) that have not responded to standard treatments. The drug works by blocking a protein cancer cells need to grow. The main goals are to check safety, find the best dose, and see if the drug shows any signs of shrinking tumors. Because this is the first time JBZ-001 is being tested in humans, the focus is on safety and dosing, not yet on proving it works.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
JBZ-001 (a drug that blocks a protein called DHODH, which cancer cells need to grow)
What this could lead to
If it works, this could point toward a new treatment option for people with advanced cancers that have not responded to other therapies.
What could go wrong
This is a very early, first-in-human trial with only 25 participants, so the drug may not be effective or could have unexpected side effects. Success in this small study does not guarantee broader benefits.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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START Mountain Region
RECRUITINGWest Valley City, Utah, 84119, United States
Contact
Contact Email: •••••@•••••
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The Ohio State University
RECRUITINGColumbus, Ohio, 43210, United States
Contact