Can a hormone blocking drug reveal why gestational diabetes happens?
NCT ID NCT07806695
First seen Sep 08, 2026 · Last updated Sep 09, 2026 · Updated 1 time
Summary
Researchers at Mayo Clinic are studying how the pancreas changes during and after pregnancy in women with gestational diabetes. The trial involves pregnant women who have completed their second-trimester screening and are classified as having gestational diabetes or not. After delivery, participants receive an infusion of exendin 9-39, a drug that blocks a hormone involved in blood sugar control, to measure how the pancreas responds to glucose. The goal is to understand the underlying function of insulin- and glucagon-producing cells, which may help explain the development of gestational diabetes.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Exendin 9-39, given as an intravenous infusion during one postpartum study visit
- What this could lead to
- If this trial succeeds, it could clarify how the pancreas adapts in pregnancy and why some women develop gestational diabetes, pointing toward better screening or prevention strategies.
- What could go wrong
- This is an early-phase study focused on measuring hormone responses, not on treating the condition. Results may not directly change clinical care, and the drug infusion may cause side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 1
The first testing in people. Mainly checks safety and dose, usually in a small group.
- Participants
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About 90 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Sep 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2030
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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20 to 40 years
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Pregnant individuals with a viable singleton pregnancy who have completed second trimester gestational diabetes screening and are eligible for classification as either gestational diabetes mellitus or no gestational diabetes mellitus. * Participants must be willing and able to provide informed consent and complete planned pregnancy and postpartum study visits. Exclusion Criteria: * Active systemic illness (e.g. chronic kidney disease, hypertension) * Pre-pregnancy diabetes mellitus * Multiple gestation, major fetal anomaly, or non-viable pregnancy on ultrasound * Fasting glucose ≥ 100 mg/dL or HbA1c ≥ 5.7% in early pregnancy * One abnormal value on the 3-hour 100 g oral glucose tolerance test * Glucose at least 190 mg/dL on glucose challenge testing without subsequent 3-hour oral glucose tolerance testing * Use of medication affecting glucose metabolism before pregnancy or in early pregnancy * Use of glucose-lowering medication (e.g. metformin, glyburide) other than insulin to treat gestational diabetes mellitus in the current pregnancy * History of upper gastrointestinal surgery that alters gastric emptying (e.g. bariatric surgery) * Hemoglobin \< than 11 g/dL
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Mayo Clinic
RECRUITINGRochester, Minnesota, 55905, United States
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- Blood sugar tracker for pregnancy diabetes: does your background matter?