Knee replacement pain relief: which catheter placement stays put?

NCT ID NCT07681622

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
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Status unknown
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First seen Jul 02, 2026 · Last updated Jul 02, 2026

Summary

This study compares two techniques for inserting a thin tube (catheter) that delivers numbing medicine to the thigh after knee replacement surgery. The goal is to see which method keeps the catheter in place better, since movement can cause it to slip and reduce pain relief. Researchers will also check pain levels and painkiller use on the first day after surgery. The trial involves 48 adults undergoing knee replacement.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
continuous adductor canal block catheter
What this could lead to
If one technique proves more stable, it could improve pain control and reduce opioid use after knee replacement surgery.
What could go wrong
This is a small, early-stage comparison study (48 participants) that may not show a clear difference between techniques. Results may not apply to all patients or surgical settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 48 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jun 2026

An estimate. Start dates often move.

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Non-pregnant patients older than 18 years of age; * Patients undergoing unilateral primary total knee arthroplasty in an inpatient regime; * American Society of Anesthesiologist (ASA) physical status Class I - IV patients; * With sufficient understanding and co-operation about usage of a perineural catheter for pain management; * With body mass index (BMI) under 45; * With no history of strong opioid use of more than 30 mg of oral morphine equivalent (OME)/day during the 2 weeks preceding the surgery; * No alcohol or drug use disorder history; * With no contra-indication for the performance of ACB and IPACK block; * With no contra-indication for spinal anesthesia; * With no contra-indication for CACB catheter insertion (local site infection, systemic infection, anatomical abnormality); * With no contra-indication for the medications to be used accordingly with the study protocol (ropivacaine, lidocaine, mepivacaine, midazolam, fentanyl, propofol, cefazolin, tranexamic acid, dexamethasone, ondansetron, celecoxib, acetaminophen, hydromorphone); * Speak and understand the English language; * Agree to participate on this study through the signature of the consent form. Exclusion Criteria: * They have a failed spinal anesthesia and needs for a conversion to general anesthesia; * The peripheral nerve blocks are not possible to be performed due to technical difficulties; * A deviation of the protocol occurs (not follow the standardized postoperative analgesia orders; need an emergency re-operation of the same knee, in less than 24 hours, due to a surgical complication; have an important perioperative complication, leading to abnormal level of conscience); * CACB catheter has issues on its function and needs to be removed before the migration assessment * Patient decides to withdraw from the study.

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As listed by the trial registrant

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How to take part

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Contacts and locations

Locations

  • Mount Sinai Hospital

    Toronto, Ontario, M5G 1X5, Canada

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