Knee replacement pain relief: which catheter placement stays put?
NCT ID NCT07681622
First seen Jul 02, 2026 · Last updated Jul 02, 2026
Summary
This study compares two techniques for inserting a thin tube (catheter) that delivers numbing medicine to the thigh after knee replacement surgery. The goal is to see which method keeps the catheter in place better, since movement can cause it to slip and reduce pain relief. Researchers will also check pain levels and painkiller use on the first day after surgery. The trial involves 48 adults undergoing knee replacement.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- continuous adductor canal block catheter
- What this could lead to
- If one technique proves more stable, it could improve pain control and reduce opioid use after knee replacement surgery.
- What could go wrong
- This is a small, early-stage comparison study (48 participants) that may not show a clear difference between techniques. Results may not apply to all patients or surgical settings.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 48 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jun 2026
An estimate. Start dates often move.
- Expected to finish
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Jun 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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21 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Non-pregnant patients older than 18 years of age; * Patients undergoing unilateral primary total knee arthroplasty in an inpatient regime; * American Society of Anesthesiologist (ASA) physical status Class I - IV patients; * With sufficient understanding and co-operation about usage of a perineural catheter for pain management; * With body mass index (BMI) under 45; * With no history of strong opioid use of more than 30 mg of oral morphine equivalent (OME)/day during the 2 weeks preceding the surgery; * No alcohol or drug use disorder history; * With no contra-indication for the performance of ACB and IPACK block; * With no contra-indication for spinal anesthesia; * With no contra-indication for CACB catheter insertion (local site infection, systemic infection, anatomical abnormality); * With no contra-indication for the medications to be used accordingly with the study protocol (ropivacaine, lidocaine, mepivacaine, midazolam, fentanyl, propofol, cefazolin, tranexamic acid, dexamethasone, ondansetron, celecoxib, acetaminophen, hydromorphone); * Speak and understand the English language; * Agree to participate on this study through the signature of the consent form. Exclusion Criteria: * They have a failed spinal anesthesia and needs for a conversion to general anesthesia; * The peripheral nerve blocks are not possible to be performed due to technical difficulties; * A deviation of the protocol occurs (not follow the standardized postoperative analgesia orders; need an emergency re-operation of the same knee, in less than 24 hours, due to a surgical complication; have an important perioperative complication, leading to abnormal level of conscience); * CACB catheter has issues on its function and needs to be removed before the migration assessment * Patient decides to withdraw from the study.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Mount Sinai Hospital
Toronto, Ontario, M5G 1X5, Canada
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