Can one spinal injection cut opioid use after chest surgery?

NCT ID NCT07790250

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 27, 2026 · Last updated Aug 28, 2026 · Updated 1 time

Summary

This trial tests whether adding a single dose of morphine into the spinal fluid, given before surgery, can reduce opioid use and improve recovery in adults undergoing open chest surgery (thoracotomy). All participants receive a standard intercostal nerve block and usual pain medication. Half also get the spinal morphine injection. Researchers measure total opioid use in the first 24 hours after surgery, pain levels, quality of recovery, and lung function.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Intrathecal morphine
What this could lead to
If it works, this could lead to a simple, single-shot way to reduce opioid use and improve recovery after open chest surgery.
What could go wrong
This is a small, early-stage trial, and the added benefit of intrathecal morphine over standard care is not yet proven. There are also risks such as respiratory depression or itching.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

60 people

The number who actually took part.

Started

Apr 2019

Finished

Jan 2021

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 years or older. * Patients scheduled for elective open thoracotomy under general anesthesia. * Patients undergoing thoracotomy through a standard posterolateral or anterolateral thoracotomy incision. * Patients eligible to receive surgeon-performed intercostal nerve blockade as part of the standard postoperative analgesic protocol. * American Society of Anesthesiologists (ASA) physical status I-III. * Ability to understand the study procedures and comply with the study assessments. * Provision of written informed consent before enrollment. Exclusion Criteria: * Age \<18 years. * Emergency or urgent thoracic surgery. * Video-assisted thoracoscopic surgery (VATS), robotic-assisted thoracic surgery, or other minimally invasive procedures without an open thoracotomy. * Previous thoracic surgery on the operative side that may significantly alter thoracic wall innervation. * Contraindication to neuraxial anesthesia or intrathecal morphine, including: * Coagulopathy or clinically significant bleeding disorder. * Therapeutic anticoagulation precluding neuraxial procedures. * Local infection at the intended puncture site or systemic infection. * Known hypersensitivity to morphine or other study medications. * Severe spinal anatomical abnormalities preventing safe intrathecal access. * Increased intracranial pressure or other contraindications to spinal anesthesia. * Chronic opioid use or long-term opioid therapy before surgery. * Pre-existing chronic pain requiring regular analgesic medication. * Severe pre-existing pulmonary disease that would substantially interfere with postoperative pulmonary function assessment. * Pre-existing neurological or neuromuscular disease that could affect respiratory function, pain assessment, or mobilization. * Severe hepatic or renal dysfunction that could significantly affect opioid metabolism or elimination. * Pregnancy or breastfeeding. * Inability to communicate adequately or reliably report pain or complete the Quality of Recovery-15 (QoR-15) questionnaire. * Inability to perform reliable preoperative or postoperative pulmonary function testing. * Any condition judged by the investigator to make participation unsafe or to interfere substantially with study outcomes. * Refusal to participate or withdrawal of informed consent.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Bursa City Hospital

    Bursa, nilüfer, 16010, Turkey (Türkiye)

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