Breathing easy: inhaled antibiotic may stop ventilator pneumonia

NCT ID NCT03149640

Completed Prevention Sponsor: University Hospital, Tours Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether giving inhaled amikacin for three days could prevent pneumonia in 850 adults on breathing machines. Patients received either the drug or a placebo starting day 4 of ventilation. The goal was to see if the treatment reduced pneumonia cases up to day 28.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: inhaled amikacin
What this could lead to: If it works, this could offer a simple way to prevent pneumonia in patients on breathing machines, reducing illness and antibiotic use.
What could go wrong: This is a completed Phase 3 trial, but results may not apply to all ICU settings. Inhaled antibiotics can cause airway irritation or resistance.

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Conditions

The condition(s) this trial relates to.

Pneumonia, Ventilator-Associated

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PNEUMONIA, VENTILATOR-ASSOCIATED

Contacts and locations

Locations

Service de Réanimation

Dijon, 21079, France
Service de Réanimation

Le Mans, 72037, France
Service de Réanimation - NHC

Strasbourg, 67091, France
Service de Réanimation Chirurgicale

Angers, 49933, France
Service de Réanimation Médicale

Orléans, 45100, France
Service de Réanimation Médicale

Poitiers, 86021, France
Service de Réanimation Médicale - CH d'Angoulême

Angoulême, 16959, France
Service de Réanimation Médicale - CHD Les Oudairies

La Roche-sur-Yon, 85025, France
Service de Réanimation Médicale - CHU La Milétrie

Poitiers, 86021, France
Service de Réanimation Médicale - CHU Pontchaillou

Rennes, 35033, France
Service de Réanimation Médicale - CHU Rouen

Rouen, 76031, France
Service de Réanimation Médicale - Hôpital Charles Nicolle

Rouen, 76031, France
Service de Réanimation Médicale - Hôpital La Croix-Rousse

Lyon, 69317, France
Service de Réanimation Médicale - Hôpital Louis Mourier

Colombes, 92700, France
Service de Réanimation Médicale - Hôpital Pitié Salpêtrière

Paris, 75013, France
Service de Réanimation Médicale - Hôpital de Hautepierre

Strasbourg, 67098, France
Service de Réanimation Polyvalente

Argenteuil, France
Service de Réanimation médicale, Hôpital Trousseau

Tours, 37044, France

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