New biomarkers could speed up pneumonia diagnosis in ICU patients

NCT ID NCT05117125

Recruiting now Diagnosis Sponsor: Region Skane Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether certain proteins, lung bacteria, and bacterial gene patterns can help predict or diagnose pneumonia in patients on breathing machines. Researchers will measure these biomarkers in 1,000 ICU patients and compare those who develop pneumonia to those who do not. The goal is to find faster, more accurate ways to diagnose ventilator-associated pneumonia.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Heparin-binding protein, Interleukin-26, lung microbiome analysis, bacterial transcriptome analysis
What this could lead to: If successful, this could lead to faster and more accurate diagnosis of ventilator-associated pneumonia, helping doctors start the right treatment sooner.
What could go wrong: This is an early-stage biomarker study, not a treatment trial. The markers may not prove accurate enough for routine use, and results may not apply to all ICU patients.

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Conditions

The condition(s) this trial relates to.

Pneumonia, Ventilator-Associated

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PNEUMONIA, VENTILATOR-ASSOCIATED

Contacts and locations

Locations

Hospital de São Francisco Xavier
RECRUITING

Lisbon, Portugal
Karolinska University Hospital, ICU
NOT_YET_RECRUITING

Solna, Sweden
Skåne University Hospital, Dept. of Infectious diseases
RECRUITING

Lund, Sweden
Skåne university Hospital, ICU
RECRUITING

Malmö, Sweden
Vestre Viken
RECRUITING

Drammen, 3004, Norway

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