New combo tackles tough pancreatic cancer

NCT ID NCT02077881

Completed Disease control Sponsor: NewLink Genetics Corporation Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested an experimental immunotherapy called indoximod added to standard chemotherapy (gemcitabine and nab-paclitaxel) in 157 people with metastatic pancreatic cancer. The goal was to find a safe dose and see if the combination helps people live longer. The trial has completed, and results will show whether adding indoximod improves outcomes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Indoximod (an experimental immunotherapy) plus gemcitabine and nab-paclitaxel (standard chemotherapy)
What this could lead to: If successful, this combination could improve survival for people with metastatic pancreatic cancer, a disease with very few treatment options.
What could go wrong: This is an early-phase trial, so the added benefit over standard chemo alone is uncertain. The immunotherapy may also increase side effects like fatigue or immune reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

adenocarcinoma malignant pancreatic neoplasm neoplasm Neoplasm Metastasis pancreatic adenocarcinoma pancreatic neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC PANCREATIC ADENOCARCINOMA METASTATIC PANCREATIC CANCER

Contacts and locations

Locations

Augusta University

Augusta, Georgia, 30912, United States
Gibbs Cancer Center and Research Institute

Spartanburg, South Carolina, 29303, United States
Greenville Health Systems

Greenville, South Carolina, 29605, United States
Huntsman Cancer Center

Salt Lake City, Utah, 84112, United States
Stanford University

Palo Alto, California, 94304, United States
The Vally Hospital

Paramus, New Jersey, 07652, United States
The West Clinic

Memphis, Tennessee, 38120, United States
University of Kentucy

Lexington, Kentucky, 40536, United States
University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, 15232, United States
University of Vermont Medical Center

Burlington, Vermont, 05401, United States
Washington University in St. Louis

St Louis, Missouri, 63110, United States

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