New hope for hard-to-treat cancers: experimental drug targets DLL3
NCT ID NCT04471727
First seen Nov 01, 2025 · Last updated May 14, 2026 · Updated 28 times
Summary
This study tests a new drug called HPN328, alone or with other medicines, in people with advanced small-cell lung cancer or neuroendocrine cancer that has DLL3 protein. The goal is to find the safest dose and see how well the body handles it. About 232 adults will take part in this early-phase trial.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Cedar-Sinai Medical Center, Samuel Oschin Comprehensive Cancer Institute
Los Angeles, California, 90048, United States
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Dana Farber Cancer Institute
Boston, Massachusetts, 02467, United States
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Karmanos Cancer Center
Detroit, Michigan, 48201, United States
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Medical College of Wisconsin
Milwaukee, Wisconsin, 53226, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10021, United States
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Providence
Portland, Oregon, 97213, United States
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Roswell Park Comprehensive Cancer Center
Buffalo, New York, 14263, United States
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Tennessee Oncology
Nashville, Tennessee, 37203, United States
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University Hospitals Cleveland Medical Center
Cleveland, Ohio, 44106, United States
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University of California San Francisco
San Francisco, California, 94143, United States
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University of Colorado
Aurora, Colorado, 80045, United States
Conditions
Explore the condition pages connected to this study.