Hormone swings linked to suicide risk in women: new study
NCT ID NCT04112368
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether stabilizing hormones with estrogen patches and progesterone pills could reduce suicidal thoughts in women with recent suicidal ideation. 124 women participated, tracking their daily mood and suicide risk over a month. The goal was to understand how natural hormone cycles influence short-term suicide risk, not to provide a treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Estradiol transdermal patch and oral micronized progesterone
What this could lead to
If successful, this could point toward a treatment that prevents monthly worsening of suicide risk in women of reproductive age.
What could go wrong
This is a small, early-phase study focused on understanding biology, not testing a treatment. The results may not lead to a direct therapy, and the hormone interventions may have side effects.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University of Illinois Neuropsychiatric Institute
Chicago, Illinois, 60612, United States