Hormone cream study aims to unlock pelvic floor secrets
NCT ID NCT01886794
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at how hormones influence vaginal tissue in women with pelvic organ prolapse (POP), a condition where pelvic organs slip out of place. Researchers compared postmenopausal women using estrogen cream or placebo to reproductive-age women, examining tissue samples from surgery. The goal was to find tissue differences that could lead to better, noninvasive treatments. However, the study was terminated early with only 7 participants, limiting its conclusions.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
topical vaginal estrogen cream
What this could lead to
If successful, this could help develop targeted, noninvasive treatments for pelvic organ prolapse by understanding tissue differences.
What could go wrong
This small, terminated Phase 4 trial had only 7 participants, so results may not be reliable or generalizable. It was exploratory, not designed to prove a treatment works.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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UTMB Galveston
Galveston, Texas, 77550, United States