Hormone cream study aims to unlock pelvic floor secrets

NCT ID NCT01886794

Terminated Knowledge-focused Sponsor: The University of Texas Medical Branch, Galveston Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at how hormones influence vaginal tissue in women with pelvic organ prolapse (POP), a condition where pelvic organs slip out of place. Researchers compared postmenopausal women using estrogen cream or placebo to reproductive-age women, examining tissue samples from surgery. The goal was to find tissue differences that could lead to better, noninvasive treatments. However, the study was terminated early with only 7 participants, limiting its conclusions.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: topical vaginal estrogen cream
What this could lead to: If successful, this could help develop targeted, noninvasive treatments for pelvic organ prolapse by understanding tissue differences.
What could go wrong: This small, terminated Phase 4 trial had only 7 participants, so results may not be reliable or generalizable. It was exploratory, not designed to prove a treatment works.

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Conditions

The condition(s) this trial relates to.

Pelvic Floor Disorders pelvic organ prolapse

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PELVIC FLOOR DISORDERS

Contacts and locations

Locations

UTMB Galveston

Galveston, Texas, 77550, United States

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