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Can a vitamin E-Infused plastic liner outlast standard liners in hip replacements?

NCT ID NCT07863557

Symptom relief Sponsor: Uppsala University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Oct 07, 2026 · Last updated Oct 09, 2026 · Updated 2 times

Summary

Researchers at Uppsala University Hospital are comparing two plastic liners used in total hip replacement: one infused with vitamin E and one standard highly crosslinked liner. Forty adults with hip osteoarthritis, osteonecrosis, or dysplasia will receive a dual mobility hip cup with one of the two liners. Using CT scans instead of standard X-rays, the team will measure how much the liner wears and whether the cup shifts over two years. The question is whether the standard liner performs as well as the vitamin E version.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a vitamin E-infused plastic liner for a hip replacement cup, compared with a standard plastic liner
What this could lead to
If the standard liner performs as well as the vitamin E version, surgeons could choose either option with confidence and possibly lower costs. If the vitamin E liner wears less, it might last longer and reduce the need for repeat surgery.
What could go wrong
The trial is small, with 40 patients, and follows them for only two years, so it cannot show how either liner holds up over a decade or more. Wear measured on CT scans may not predict real-world implant failure, and the results may not apply to other hip replacement designs.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2026

Expected to finish

Oct 2033

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18-75 years * Written informed consent * Eligible for a Total Hip Arthroplasty according to local guidelines and appropriate candidate for a dual mobility concept * Diagnosis: Symptomatic osteoarthritis, osteonecrosis, or dysplasia of the hip requiring a hip replacement Exclusion Criteria: * Confirmed dementia or cognitive impairment * Unwillingness to give written informed consent * Age \<18 or \>75 years * Hip fracture (traumatic or pathological) in need of a Total Hip Arthroplasty * Patients who are not deemed suitable for a THA with a Dual Mobility Cup according to local guidelines and routines * Comorbidities that are contraindicators for hip replacement surgery

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Conditions

The condition(s) this trial relates to.

developmental dysplasia of the hip Hip Dislocation osteoarthritis osteoarthritis, hip osteonecrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dysplasia; hip Osteoarthritis Osteonecrosis

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Uppsala University Hospital

    RECRUITING

    Uppsala, Uppsala County, 751 85, Sweden

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