Can High-Flow oxygen make it easier to breathe without a ventilator?
NCT ID NCT07724392
First seen Jul 24, 2026 · Last updated Jul 24, 2026
Summary
This study compares three methods of supporting breathing during a spontaneous breathing trial — the test used to see if a patient can be safely taken off a ventilator. The methods are a standard T-piece, pressure support ventilation, and high-flow humidified oxygen. The goal is to measure how much energy patients expend to breathe with each method. The trial enrolls 30 adults in the ICU who have been on a ventilator for more than 48 hours and are at high risk of extubation failure.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- high-flow humidified oxygen delivered via a device normally used for tracheostomies
- What this could lead to
- If high-flow oxygen reduces the work of breathing during weaning, it could lead to a better method for deciding when to remove the breathing tube, potentially reducing complications.
- What could go wrong
- This is a small, early physiological study in 30 people, not a large trial. It measures breathing effort, not patient outcomes, so even positive results may not translate to real-world benefits.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 30 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jan 2027
An estimate. Start dates often move.
- Expected to finish
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Jan 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adult patient, of legal age * On invasive mechanical ventilation for more than 48 hours * With at least one criterion indicating a high risk of extubation failure: * Age \> 65 years * Chronic respiratory disease * Chronic cardiac disease * Capable of undergoing a mechanical ventilation weaning test ("weaning criterion"): * Respiratory rate \< 35 bpm * Adequate oxygenation: * SpO₂ ≥ 90% with FiO₂ ≤ 40% and PEEP ≤ 8 cm H₂O * Or PaO₂/FiO₂ ≥ 150 with PEEP ≤ 8 cm H₂O * Effective cough * Patient is alert (RASS score -2 to +1), without sedation * Hemodynamically stable or on the minimum effective dose * Patient has an invasive arterial pressure catheter for arterial blood sampling * Informed consent signed by a family member * Patient is enrolled in or eligible for a social security program Exclusion Criteria: * Resuscitation-associated neuromyopathy * History of neuromuscular disease * Admission for a neurological condition * Subjects currently excluded from another study, * Persons referred to in Articles L1121-5 through L1121-8 of the CSP (corresponding to all protected persons: pregnant women, women in labor, breastfeeding mothers, persons deprived of liberty by judicial or administrative decision, persons receiving psychiatric care pursuant to Articles L. 3212-1 and L. 3213-1 who are not covered by the provisions of Article L. 1121-8, persons admitted to a health or social care facility for purposes other than research, minors, and persons subject to a legal protection order or unable to give informed consent). * Staff members who report to the principal investigator
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
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