Which breathing test helps ICU patients get off ventilators faster?
NCT ID NCT07005505
First seen Jul 02, 2026 · Last updated Jul 02, 2026
Summary
This study compares two methods of spontaneous breathing trials (SBTs) in critically ill adults who have been on a breathing machine for over 24 hours. The goal is to see whether automatic tube compensation (ATC) or pressure support ventilation (PSV) leads to more successful removal of the breathing tube. Researchers will track outcomes like reintubation and death to determine which approach is safer and more effective.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Automatic tube compensation (ATC) and pressure support ventilation (PSV)
- What this could lead to
- If one method proves superior, it could become the standard approach for weaning patients off ventilators, potentially reducing complications and deaths.
- What could go wrong
- This is a single-center study, and results may not apply to all ICUs. The difference between methods may be small or not clinically meaningful.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
About 880 people
The number the study aims to enrol. It can still change while the study runs.
- Started
-
Jun 2025
- Expected to finish
-
Aug 2027
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Admitted to intensive care unit (ICU) * Age 18 years or older * Requiring invasive mechanical ventilation for at least 24 hours * Pass spontaneous breathing trial screen criteria Exclusion Criteria: * Clinical decision made not to proceed with extubation regardless of spontaneous breathing trial (SBT) results * Do not intubate (DNI) order * Presence of tracheostomy * Pregnancy * Known prisoner * Immediate need for extubation, self-extubation, or unplanned extubation that precludes safe performance of study procedures * Enrolled in another clinical trial that impacts ventilator weaning or liberation
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Spontaneous breathing trial in icu are added.
By submitting, you agree to our Terms of use
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
-
The places running it
1 site. The list below names each one and where it is.
-
The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
-
A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
-
Rush University Medical Center
RECRUITINGChicago, Illinois, 60612, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.