New combo therapy aims to keep advanced breast cancer in check
NCT ID NCT06172127
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial tests a two-step treatment for people with HER2-positive breast cancer that has spread or cannot be removed by surgery. First, patients receive a strong drug called trastuzumab deruxtecan (T-DXd) to shrink the cancer. Then, they switch to a maintenance therapy of two other drugs (trastuzumab and pertuzumab, given as a shot) to keep the cancer from growing. The study includes 165 adults and measures how long the cancer stays under control and overall survival. This is not a cure, as ongoing treatment is needed.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Consorci Hospital General Universitari de València
Valencia, Spain
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Fondazione Policlinico Universitario Agostino Gemelli
Roma, Italy
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Hopital Europeen Georges Pompidou
Paris, France
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Hospital Arnau de Vilanova de Valencia
Valencia, Spain
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Hospital Beata María Ana
Madrid, Spain
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Hospital Clínic i Provincial de Barcelona
Barcelona, Spain
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Hospital Clínico San Carlos
Madrid, Spain
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Hospital Clínico Universitario de Valencia
Valencia, Spain
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Hospital General Universitario Dr. Balmis (Alicante)
Alicante, Spain
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Hospital Provincial de Castellón
Castellon, Spain
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Hospital Quirónsalud Sagrado Corazón
Seville, Spain
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Hospital Universitari Dexeus
Barcelona, Spain
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Hospital Universitario Clínico San Cecilio de Granada
Granada, Spain
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Hospital Universitario La Paz
Madrid, Spain
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Hospital Universitario Ramón y Cajal
Madrid, Spain
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Hospital Universitario Reina Sofía
Córdoba, Spain
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Hospital Universitario Virgen Macarena
Seville, Spain
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Hospital Universitario Virgen de la Victoria
Málaga, Spain
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Hospital Universitario Virgen del Rocío
Seville, Sevilla, Spain
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Hospital Universitario de Basurto
Bilbao, Spain
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Hospital Universitario de León
León, Spain
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Hospital del Vinalopó
Alicante, Spain
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Humanitas Gavazzeni
Bergamo, Italy
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Hôpital Tenon AP-HP
Paris, France
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Institut Català d' Oncologia L'Hospitalet (ICO)
Barcelona, Spain
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Institute Paoli Calmettes
Marseille, France
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Instituto Europeo di Oncologia
Milan, Italy
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Instituto Valenciano de Oncología (IVO)
Valencia, Spain
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Kliniken Essen Mitte
Essen, Germany
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Klinikum der Universität München
München, Germany
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MD Anderson Cancer Center Madrid
Madrid, Spain
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Mammazentrum HH
Hamburg, 20357, Germany
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Marienhospital Bottrop GmbH Klinik für Gynäkologie und Geburtshilfe
Bottrop, 46236, Germany
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Northwell Health
New York, New York, 11040, United States
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University Hospital Maggiore della Carita
Novara, Italy