Heart showdown: can a Kidney-Targeting drug beat a standard pill for obese patients?

NCT ID NCT04519164

First seen Nov 01, 2025 · Last updated May 23, 2026 · Updated 21 times

Summary

This study compared two blood pressure medicines—eplerenone and chlorthalidone—in 79 adults with obesity and high blood pressure or metabolic syndrome. The goal was to see if eplerenone could improve blood flow to the heart and reduce scarring, beyond just lowering blood pressure. Participants took one of the two drugs for 12 weeks and had heart MRI scans before and after treatment.

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Contacts and locations

Locations

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02115, United States

Conditions

Explore the condition pages connected to this study.