Heart failure drug trial halted early

NCT ID NCT05592275

Summary

This study tested whether an experimental drug called LY3540378 could help adults with a specific type of worsening heart failure where the heart pumps normally but doesn't relax properly. The trial enrolled 332 participants who had recently been hospitalized or needed urgent treatment for heart failure symptoms. It was a Phase 2 study that was terminated early, and its main goal was to see if the drug improved heart function measurements and was safe over 26 weeks.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • 1 Wojskowy Szpital Kliniczny w Lublinie

    Lublin, Lublin Voivodeship, 20-043, Poland

  • Abington Memorial Hospital

    Abington, Pennsylvania, 19001, United States

  • Afyon Kocatepe Üniversitesi Tıp Fakültesi

    Afyonkarahisar, 03030, Turkey (Türkiye)

  • Aintree University Hospital NHS Foundation Trust

    Liverpool, L9 7AL, United Kingdom

  • Ankara Etlik City Hospital

    Ankara, 06170, Turkey (Türkiye)

  • Balsam Medica

    Warsaw, Masovian Voivodeship, 01-249, Poland

  • Baylor Scott & White Health-Advanced Heart and Lung Disease

    Dallas, Texas, 75246, United States

  • Belvárosi Egészségház

    Zalaegerszeg, Zala County, 8900, Hungary

  • Boston Medical Center

    Boston, Massachusetts, 02118, United States

  • Bursa Yüksek İhtisas Eğitim Ve Araştırma Hastanesi

    Yıldırım, Bursa, 16310, Turkey (Türkiye)

  • CAPED Centro Avancado Pesquisa e Diagnostica

    Ribeirão Preto, São Paulo, 14026-900, Brazil

  • CEMEDIC

    Buenos Aires, 1407, Argentina

  • CHUS - Hospital Clinico Universitario

    Santiago de Compostela, A Coruña [La Coruña], 15706, Spain

  • CPS Research

    Waterloo, Ontario, N2T 0C1, Canada

  • CenterMed Lublin NZOZ

    Lublin, Lublin Voivodeship, 20-044, Poland

  • Centre Hospitalier Universite de Sherbrooke - Hôtel-Dieu Hospital

    Sherbrooke, Quebec, J1G 2E8, Canada

  • Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada

    Buenos Aires, Buenos Aires F.D., C1425AGC, Argentina

  • Centro de Investigaciones Clinicas del Litoral

    Santa Fe, 3000, Argentina

  • Centro de Investigaciones Metabólicas (CINME)

    Ciudad Autónoma de Buenos Aires, Buenos Aires, C1056ABI, Argentina

  • Centro de Pesquisa Clinica do Coracao

    Acaraju, Sergipe, 49055-530, Brazil

  • Centro de Pesquisa Sao Lucas

    Campinas, São Paulo, 13034-685, Brazil

  • Centro de Pesquisa Silvestre Santé

    Rio Branco, Acre, 69915-030, Brazil

  • Clínica de Nefrología, Urología y Enfermedades Cardiovasculares

    Santa Fe, 3000, Argentina

  • Dokuz Eylul Universitesi Hastanesi

    Izmir, 35330, Turkey (Türkiye)

  • Dél-Pesti Centrumkórház

    Budapest, 1097, Hungary

  • Ege Universitesi Hastanesi

    Bornova, İzmir, 35100, Turkey (Türkiye)

  • Eskisehir Osmangazi University

    Eskişehir, Eskişehir, 26480, Turkey (Türkiye)

  • Excel Medical Clinical Trials

    Boca Raton, Florida, 33434, United States

  • Fakultni Nemocnice u sv. Anny v Brne

    Brno, South Moravian, 60200, Czechia

  • Fakultní nemocnice Brno Bohunice

    Brno, Brno-město, 62500, Czechia

  • Fundación Respirar

    Buenos Aires, C1426ABP, Argentina

  • Glasgow Royal Infirmary

    Glasgow, Scotland, G31 2ER, United Kingdom

  • Gunma University Hospital

    Maebashi, Gunma, 371-8511, Japan

  • Hadassah Medical Center

    Jerusalem, Jerusalem, 9112001, Israel

  • Harasanshin Hospital

    Fukuoka, 812-0033, Japan

  • Heart Health Institute - Scarborough Office

    Scarborough Village, Ontario, M1B 4Z8, Canada

  • Henry Ford Hospital

    Detroit, Michigan, 48202, United States

  • Hospital Clinico de Valencia

    Valencia, Valenciana, Comunitat, 46010, Spain

  • Hospital Clínico Universitario Virgen de la Arrixaca

    El Palmar, Murcia, Murcia, Región de, 30120, Spain

  • Hospital Germans Trias i Pujol

    Badalona, Barcelona [Barcelona], 08916, Spain

  • Hospital Provincial del Centenario

    Rosario, Santa Fe Province, 2002, Argentina

  • Hospital San Juan de la Cruz

    Úbeda, Jaén, 23400, Spain

  • Hospital Santa Paula

    São Paulo, São Paulo, 04556-100, Brazil

  • Hospital São Lucas de Copacabana

    Rio de Janeiro, 22061-080, Brazil

  • Hospital Universitari de Bellvitge

    L'Hospitalet de Llobregat, Catalunya [Cataluña], 08907, Spain

  • Hospital Universitario 12 de Octubre

    Madrid, 28041, Spain

  • Hospital Universitario Ramón y Cajal

    Madrid, Madrid, Comunidad de, 28034, Spain

  • Hospital Universitario Reina Sofia

    Córdoba, Andalusia, 14004, Spain

  • Hospital Universitario Virgen de Valme

    Seville, Andalusia, 41014, Spain

  • Hospital Universitario Virgen de la Victoria

    Málaga, Málaga, 29010, Spain

  • Hospital de Denia Marina Salud

    Denia, Alicante, 03700, Spain

  • INTERCOR

    Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-605, Poland

  • IRMED Osrodek Badan Klinicznych

    Piotrkow Trybunalski, Łódź Voivodeship, 97-300, Poland

  • Incor - Instituto do Coracao

    São Paulo, São Paulo, 05403-900, Brazil

  • Infinite Clinical Research

    Miami, Florida, 33133, United States

  • Instituto D'Or Pesquisa e Ensino

    Rio de Janeiro, 22281-100, Brazil

  • Instituto Do Coracao De Marilia

    Marília, São Paulo, 17515-000, Brazil

  • Instituto Médico Río Cuarto

    Río Cuarto, Córdoba Province, 5800, Argentina

  • Instituto de Investigaciones Clinicas Rosario

    Rosario, Santa Fe Province, S2000CVD, Argentina

  • Instituto de Investigaciones Clinicas Zarate

    Zárate, Buenos Aires, B2800DGH, Argentina

  • Instituto de Molestias Cardiovasculares de Tatui

    Tatuí, São Paulo, 18270-170, Brazil

  • Instituto de Pesquisa clinica de Campinas

    Campinas, São Paulo, 13060-080, Brazil

  • Integral Pesquisa e Ensino

    Votuporanga, São Paulo, 15501-405, Brazil

  • Investigaciones Clínicas Tucumán

    San Miguel de Tucumán, Tucumán Province, 4000, Argentina

  • Investigaciones Medicas Imoba Srl

    Balvanera, Buenos Aires F.D., C1056ABH, Argentina

  • Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital

    Nagoya, Aichi-ken, 466-8650, Japan

  • KLIMED Marek Klimkiewicz

    Bialystok, Podlaskie Voivodeship, 15-704, Poland

  • Kanagawa Cardiovascular and Respiratory Center

    Yokohama, Kanagawa, 236-0051, Japan

  • Kasugai Municipal Hospital

    Kasugai, Aichi-ken, 486-8510, Japan

  • Kistarcsai Flor Ferenc Korhaz

    Kistarcsa, Pest County, 2143, Hungary

  • Kocaeli Üniversitesi

    İzmit, Kocaeli, 41380, Turkey (Türkiye)

  • MEDICOME Centrum Badań Klinicznych Oświęcimskie

    Oświęcim, Lesser Poland Voivodeship, 32-660, Poland

  • Mautalen Salud e Investigación

    Buenos Aires, Buenos Aires F.D., C1128AAF, Argentina

  • Mayo Clinic in Rochester, Minnesota

    Rochester, Minnesota, 55905, United States

  • Medicus MFC Research Clinic

    Toronto, Ontario, M4P 1E4, Canada

  • Medifarma 98 Kft

    Nyíregyháza, Nyíregyháza, 4400, Hungary

  • Mersin University

    Mersin, 33343, Turkey (Türkiye)

  • Minamino Cardiovascular Hospital

    Hachiōji, Tokyo, 192-0918, Japan

  • NZOZ Centrum Medyczne KERmed

    Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-231, Poland

  • Nakamura Cardiovascular Clinic

    Itoshima, Fukuoka, 819-1104, Japan

  • National Hospital Organization - Osaka National Hospital - Institute For Clinical Research

    Osaka, 540-0006, Japan

  • National Hospital Organization Okayama Medical Center

    Okayama, 701-1154, Japan

  • National Hospital Organization Takasaki General Medical Centar

    Takasaki, Gunma, 370-0829, Japan

  • North York Diagnostic and Cardiac Centre

    North York, Ontario, M6B 3H7, Canada

  • Northwick Park Hospital

    Harrow, London, City of, HA1 3UJ, United Kingdom

  • Oakville Trafalgar Memorial Hospital

    Oakville, Ontario, L6M 1M1, Canada

  • Ome Medical Center

    Ōme, Tokyo, 198-0042, Japan

  • PACE Cardiology

    Newmarket, Ontario, L3Y 2P6, Canada

  • PUC Trials- Nucleo de Pesquisa clinica da Escola de Medicina da PUCPR

    Curitiba, Paraná, 80230-130, Brazil

  • Pasadena Clinical Research

    Pasadena, California, 91105, United States

  • Pesquisare Saude

    Santo André, São Paulo, 09080-110, Brazil

  • PharmaTex Research

    Amarillo, Texas, 79109, United States

  • Pima Heart

    Tucson, Arizona, 85719, United States

  • Private Practice - Dr. Ewa Mirek Bryniarska

    Krakow, Lesser Poland Voivodeship, 30-082, Poland

  • Private Practice - Dr. Saul Vizel

    Cambridge, Ontario, N1R 7R1, Canada

  • Provita Profamilia

    Piotrkow Trybunalski, Łódź Voivodeship, 97-300, Poland

  • Raigmore Hospital

    Inverness, Highland, IV2 3JH, United Kingdom

  • Rakuwakai Otowa Hospital

    Kyoto, 607-8062, Japan

  • Rambam Health Care Campus

    Haifa, Northern District, 3109601, Israel

  • Royal Berkshire Hospital

    Reading, RG1 5AN, United Kingdom

  • SMH Cardiology Clinical Trials

    Surrey, British Columbia, V3V 0C6, Canada

  • SPZOZ Uniwersytecki Szpital Kliniczny Im. Wojskowej Akademii Medycznej UM W Łodzi Centralny Szpital Wetera -T

    Lodz, Łódź Voivodeship, 90-549, Poland

  • Saiseikai Futsukaichi Hospital

    Chikushino-shi, Fukuoka, 818-8516, Japan

  • Sakurabashi Watanabe Advanced Healthcare Hospital

    Osaka, 530-0005, Japan

  • Sanatorio Anchorena Recoleta

    Buenos Aires, Buenos Aires F.D., 1425, Argentina

  • Sanatorio San Martin

    Venado Tuerto, Santa Fe Province, 2600, Argentina

  • Semmelweis University

    Budapest, 1122, Hungary

  • Sourasky Medical Center

    Tel Aviv, Tell Abīb, 6423906, Israel

  • South Florida Research Solutions - North Flamingo Road

    Pembroke Pines, Florida, 33028, United States

  • Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ

    Szeged, Csongrád megye, 6720, Hungary

  • T.C. Sağlık Bakanlığı İzmir Tepecik Eğitim ve Araştırma Hast

    Izmir, 35120, Turkey (Türkiye)

  • Texas Institute of Cardiology, PA

    McKinney, Texas, 75071, United States

  • Toyama Prefectural Central Hospital

    Toyama, 930-0975, Japan

  • Trakya University Medical Faculty Hospital

    Edirne, 22030, Turkey (Türkiye)

  • UT Southwestern Medical Center

    Dallas, Texas, 75390, United States

  • Universidade Federal de Goias

    Goiânia, Goiás, 74605-020, Brazil

  • University Medical Center New Orleans

    New Orleans, Louisiana, 70112, United States

  • University of California Irvine Medical Center

    Orange, California, 92868, United States

  • University of North Carolina Medical Center

    Chapel Hill, North Carolina, 27514, United States

  • University of Texas Medical Branch

    Galveston, Texas, 77555-0553, United States

  • University of Wisconsin Hospital and Clinics

    Madison, Wisconsin, 53792, United States

  • Uniwersytecki Szpital Kliniczny w Białymstoku

    Bialystok, Podlaskie Voivodeship, 15-540, Poland

  • Valley Clinical Trials, Inc.

    Covina, California, 91723, United States

  • Valley Clinical Trials, Inc.

    Northridge, California, 91325, United States

  • Velocity Clinical Research, Coastal Heart Medical Group

    Santa Ana, California, 92704, United States

  • Vseobecna fakultni nemocnice v Praze

    Prague, 12808, Czechia

  • West Houston Area Clinical Trial Consultants

    Houston, Texas, 77094, United States

  • West Middlesex University Hospital

    Isleworth, TW7 6AF, United Kingdom

  • Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu

    Przemyśl, Podkarpackie Voivodeship, 37-700, Poland

  • Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Lodzi

    Lodz, Łódź Voivodeship, 93-513, Poland

  • Wycombe General Hospital

    High Wycombe, Buckinghamshire, HP11 2TT, United Kingdom

  • Wythenshawe Hospital

    Manchester, M23 9LT, United Kingdom

  • Yamanashi Prefectural Central Hospital

    Kofu, Yamanashi, 400-8506, Japan

  • Yitzhak Shamir Medical Center

    Ẕerifin, Central District, 609300, Israel

  • Yodogawa Christian Hospital

    Osaka, 533-0024, Japan

  • Yokohama City University Medical Center

    Yokohama, Kanagawa, 232-0024, Japan

  • Yokohama Minami Kyosai Hospital

    Yokohama, Kanagawa, 236-0037, Japan

Conditions

Explore the condition pages connected to this study.