New hope for sickle cell: Half-Matched transplants show promise
NCT ID NCT03263559
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial tested a half-matched (haploidentical) bone marrow transplant in 95 children and adults with severe sickle cell disease. The goal was to see if this approach could help patients live without major complications for two years. Participants received a reduced-intensity conditioning regimen before the transplant. The study found that many patients achieved event-free survival, suggesting this could be a viable option for those without a fully matched donor.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
bone marrow transplant from a half-matched donor
What this could lead to
If successful, this approach could offer a treatment option for severe sickle cell disease patients who lack a fully matched donor.
What could go wrong
This is a phase 2 trial with 95 participants, so results are still early. Risks include graft failure, infection, and graft-versus-host disease. Lifelong immunosuppression may be needed.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for SICKLE CELL DISEASE are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Cardinal Glennon Children's Hospital
St Louis, Missouri, 63104, United States
-
Children's Hospital of Michigan
Detroit, Michigan, 48201, United States
-
Children's National Medical Center
Washington D.C., District of Columbia, 20010, United States
-
Cleveland Clinic Foundation
Cleveland, Ohio, 44195, United States
-
Duke University Medical Center
Durham, North Carolina, 27705, United States
-
Fred Hutchinson Cancer Research Center
Seattle, Washington, 98109, United States
-
H. Lee Moffitt Cancer Center
Tampa, Florida, 33612, United States
-
Hackensack University Medical Center
Hackensack, New Jersey, 07601, United States
-
Helen Devos Children's at Spectrum Health
Grand Rapids, Michigan, 49503, United States
-
Indiana University Medical Center
Indianapolis, Indiana, 46202, United States
-
Johns Hopkins University
Baltimore, Maryland, 21287, United States
-
Levine Children's Hospital
Charlotte, North Carolina, 28203, United States
-
Methodist Healthcare/West Cancer Center
Memphis, Tennessee, 38104, United States
-
Nationwide Children's Hospital
Columbus, Ohio, 43205-2696, United States
-
Nicklaus Children's Hospital/University of Miami Children's Hospital
Miami, Florida, 33155, United States
-
Northside Hospital
Atlanta, Georgia, 30342, United States
-
Northwell Health/Monter Cancer Center
Lake Success, New York, 11042, United States
-
Riley Children's Hospital at IU Health
Indianapolis, Indiana, 46020, United States
-
Roswell Park Cancer Center
Buffalo, New York, 14203, United States
-
St. Jude Children's Research Hospital
Memphis, Tennessee, 38105, United States
-
Texas Children's Hospital (Baylor)
Houston, Texas, 77030, United States
-
Texas Transplant Institute
San Antonio, Texas, 78229, United States
-
The Medical College of Wisconsin
Wauwatosa, Wisconsin, 53226, United States
-
UCSF Benioff Children's Hospital Oakland
Oakland, California, 94609, United States
-
University Hospitals of Cleveland/Case Western
Cleveland, Ohio, 44106, United States
-
University of Alabama at Birmingham
Birmingham, Alabama, 35294, United States
-
University of Colorado - Denver/Children's Hospital of Colorado
Aurora, Colorado, 80045, United States
-
University of Florida College of Medicine
Gainesville, Florida, 32610, United States
-
University of Pittsburgh
Pittsburgh, Pennsylvania, 15260, United States
-
University of Texas/MD Anderson Cancer Center
Houston, Texas, 77030, United States
-
Vanderbilt University Medical Center
Nashville, Tennessee, 37232, United States
-
Washington University, St. Louis
St Louis, Missouri, 63110, United States