Gut check: do probiotics or postbiotics help during antibiotics?

NCT ID NCT07594860

Not yet recruiting Knowledge-focused Sponsor: The Archer-Daniels-Midland Company Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether taking a probiotic (live bacteria) or a postbiotic (heat-inactivated bacteria) can keep the gut microbiome healthy while people take antibiotics. About 126 healthy adults will receive one of these supplements or a placebo daily for 28 days. Researchers will measure changes in gut bacteria diversity to see if either supplement helps maintain balance.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: probiotic (live bacteria) and postbiotic (heat-inactivated bacteria)
What this could lead to: If it works, this could point toward a simple supplement to protect gut health during antibiotic use.
What could go wrong: This is a small, early pilot study in healthy adults, so results may not apply to sick people or lead to a proven product. The supplements may show no benefit over placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Dysbiosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MICROBIOME

Contacts and locations

Locations

General Hospital of Thessaloniki Papageorgiou

Thessaloniki, 56429, Greece

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