New gut cleaner could make colon surgery safer
NCT ID NCT07180615
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tests whether a gut-cleaning routine using rifaximin works as well as the standard neomycin/metronidazole combination to prevent infections after colon surgery. About 458 adults having planned colon surgery will take one of the two treatments the day before surgery. Researchers will track infections, deaths, and hospital stay length for 30 days after surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Rifaximin (Xifaxan) or Neomycin/Metronidazole
What this could lead to
If it works, this could offer a simpler, better-tolerated gut-cleaning option before colon surgery to reduce infection risk.
What could go wrong
This is a phase 4 trial comparing two established drugs, so major surprises are unlikely. The main risk is that rifaximin may not prevent infections as effectively as the standard combination.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Kantonsspital Aarau
Aarau, 5001, Switzerland
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Kantonsspital St. Gallen
Sankt Gallen, 9007, Switzerland
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Luzerner Kantonsspital
Lucerne, 6006, Switzerland
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Stadtspital Triemli
Zurich, 8063, Switzerland