Gut bugs linked to transplant complication risk

NCT ID NCT05186857

Ongoing Knowledge-focused Sponsor: Fundación Pública Andaluza para la gestión de la Investigación en Sevilla Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how changes in gut bacteria and their byproducts after a stem cell transplant might influence the development of graft-versus-host disease (GVHD), a serious complication. Researchers will collect stool and blood samples from 88 transplant recipients and their donors at several time points. By analyzing these samples, they hope to find patterns that predict GVHD and overall survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could help doctors predict and prevent graft-versus-host disease by monitoring gut health, leading to better survival after transplant.
What could go wrong: This is an observational study, not a treatment trial. It may not find a clear link, and results may not lead to immediate changes in patient care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

graft versus host disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GRAFT-VERSUS-HOST DISEASE

Contacts and locations

Locations

Hospital Clínico de Salamanca

Salamanca, Salamanca, Spain
Hospital Clínico de Valencia

Valencia, Valencia, Spain
Hospital La Paz, Madrid

Madrid, Madrid, Spain
Hospital Marqués de Valdecillas, Santander

Santander, Cantabria, Spain
Hospital Regional Universitario de Málaga

Málaga, Málaga, Spain
Hospital Universitario Reina Sofía

Córdoba, Córdoba, Spain
Hospital Universitario Virgen del Rocío, Sevilla

Seville, Seville, Spain
Hospital Virgen de las Nieves de Granada

Granada, Granada, Spain
Hospital del Niño Jesús, Madrid

Madrid, Madrid, Spain

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