Gene therapy shot for dry AMD shows early promise in small trial

NCT ID NCT03846193

First seen Feb 02, 2026 · Last updated Apr 28, 2026 · Updated 9 times

Summary

This study tested a single injection of a gene therapy called GT005 in 56 people with dry age-related macular degeneration (AMD), a leading cause of vision loss. The goal was to check safety and find the right dose. The trial was stopped early, but the results help researchers understand how to treat this eye disease.

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Contacts and locations

Locations

  • Bristol Eye Hospital

    Bristol, United Kingdom

  • Cincinnati Eye Institute

    Cincinnati, Ohio, 45242, United States

  • Manchester Eye Hospital

    Manchester, United Kingdom

  • Mid-Atlantic Retina

    Philadelphia, Pennsylvania, 19107, United States

  • Midwest Eye Institute

    Indianapolis, Indiana, 46290, United States

  • Moorfields Eye Hospital

    London, United Kingdom

  • Ophthalamic Consultants of Boston (OCB)

    Boston, Massachusetts, 02114, United States

  • Oxford University Hospital

    Oxford, United Kingdom

  • Pepose Vision Institute

    Chesterfield, Missouri, 63017, United States

  • Retina Clinic London

    London, W1G 7LA, United Kingdom

  • Sierra Eye Associates

    Reno, Nevada, 89502, United States

  • Sunderland Eye Infirmary

    Sunderland, United Kingdom

  • Wolfe Eye Clinic

    West Des Moines, Iowa, 50266, United States

Conditions

Explore the condition pages connected to this study.