New 'Go-Slow' drug combo aims to help frailest myeloma patients
NCT ID NCT06517017
First seen Nov 01, 2025 · Last updated Jun 20, 2026 · Updated 37 times
Summary
This phase 2 trial tests a gentler way to start treatment for ultra-frail patients newly diagnosed with multiple myeloma. Instead of giving all three drugs at once, doctors begin with just isatuximab and dexamethasone, then slowly add lenalidomide after two cycles. The goal is to see if this gradual approach helps patients stick with treatment and improves their quality of life. About 40 participants will be enrolled.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Huntsman Cancer Institute at the University of Utah
RECRUITINGSalt Lake City, Utah, 84112, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Isatuximab, dexamethasone, and lenalidomide
What this could lead to
If successful, this gentle approach could help ultra-frail patients with multiple myeloma stay on treatment longer and have a better quality of life.
What could go wrong
This is a small, early-phase trial with only 40 participants, so results may not apply to all patients. The go-slow method might not control the cancer as effectively as standard treatment.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.