PLASMA CELL LEUKEMIA

This study tests a new treatment plan for people newly diagnosed with primary plasma cell leukemia, a rare and aggressive blood cancer. The approach combines standard chemotherapy drugs with two rounds of CAR T-cell therapy and a stem cell transplant. The goal is to see if this i…

This study tests a new treatment for people with blood cancers like leukemia, lymphoma, or multiple myeloma that have come back or not responded to standard therapy. Participants receive donor immune cells (NK cells) that are engineered to better target cancer, along with chemoth…

This study uses a cord blood transplant after strong chemotherapy and radiation to treat various blood cancers like leukemia and lymphoma. About 200 participants will receive the transplant to see if it improves survival one year later. The approach aims to replace diseased bone …

This program provides early access to venetoclax, a targeted therapy for several blood cancers including chronic lymphocytic leukemia (CLL), acute myeloid leukemia (AML), and multiple myeloma. It is for people who have no other suitable treatments and cannot join a clinical trial…

This study tests a 'go-slow' approach for ultra-frail patients newly diagnosed with multiple myeloma. Instead of starting all drugs at once, treatment begins with just two medications (isatuximab and dexamethasone), then adds a third (lenalidomide) after two months. The goal is t…

This study tests whether the drug budesonide can prevent severe diarrhea in people with multiple myeloma who are receiving a stem cell transplant. About 120 adults will be randomly assigned to get either budesonide or a placebo alongside standard care. The goal is to see if the d…

This study is building a registry of 2,000 adults with plasma cell disorders, such as multiple myeloma and amyloidosis. Participants fill out health questionnaires and may give a blood sample to study aging markers. The goal is to gather information to help future research, not t…

This study collects blood and tissue samples from 6,000 people with multiple myeloma, smoldering myeloma, plasma cell leukemia, or MGUS. Researchers will store these samples in a biobank to study the diseases and improve future care. Participants do not receive any treatment as p…

This study is building a registry of 5,000 adults aged 50 and older with blood cancers like multiple myeloma and lymphoma. Researchers will track frailty and other age-related health issues using surveys and simple physical tests. The goal is to learn more about this group to gui…